Levels of peripheral T cell tolerance induced by different doses of tolerogen - PubMed (original) (raw)
. 1994 Feb 4;263(5147):674-6.
doi: 10.1126/science.8303275.
Affiliations
- PMID: 8303275
- DOI: 10.1126/science.8303275
Levels of peripheral T cell tolerance induced by different doses of tolerogen
I Ferber et al. Science. 1994.
Abstract
Antigen-specific immunosuppression requires an understanding of the parameters that control peripheral T cell tolerance. A liver-specific inducible promoter was used to drive the expression of the major histocompatibility complex antigen Kb in transgenic mice. Minute amounts of Kb, expressed exclusively on hepatocytes, induced tolerance by partial down-regulation of the T cell receptor (TCR) on the self-reactive CD8+ cells. Contact of these tolerant T cells with high concentrations of Kb after induction led to complete down-regulation of TCR. Thus, tolerant T cells are susceptible to further tolerogenic signals and reach different levels of tolerance depending on antigen dose.
Similar articles
- Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen.
Schönrich G, Momburg F, Malissen M, Schmitt-Verhulst AM, Malissen B, Hämmerling GJ, Arnold B. Schönrich G, et al. Int Immunol. 1992 May;4(5):581-90. doi: 10.1093/intimm/4.5.581. Int Immunol. 1992. PMID: 1627495 - Tolerance induction as a multi-step process.
Schönrich G, Alferink J, Klevenz A, Küblbeck G, Auphan N, Schmitt-Verhulst AM, Hämmerling GJ, Arnold B. Schönrich G, et al. Eur J Immunol. 1994 Feb;24(2):285-93. doi: 10.1002/eji.1830240202. Eur J Immunol. 1994. PMID: 8299678 - Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism.
Husbands SD, Schönrich G, Arnold B, Chandler PR, Simpson E, Philpott KL, Tomlinson P, O'Reilly L, Cooke A, Mellor AL. Husbands SD, et al. Eur J Immunol. 1992 Oct;22(10):2655-61. doi: 10.1002/eji.1830221027. Eur J Immunol. 1992. PMID: 1396970 - Induction of tolerance in mature peripheral T cells.
Arnold B, Schönrich G, Hämmerling GJ. Arnold B, et al. Exp Nephrol. 1993 Mar-Apr;1(2):72-7. Exp Nephrol. 1993. PMID: 8081959 Review. - Peripheral tolerance as a multi-step mechanism.
Hämmerling GJ, Schönrich G, Ferber I, Arnold B. Hämmerling GJ, et al. Immunol Rev. 1993 Jun;133:93-104. doi: 10.1111/j.1600-065x.1993.tb01511.x. Immunol Rev. 1993. PMID: 8225373 Review. No abstract available.
Cited by
- Avatrombopag for the salvage treatment of platelet transfusion refractoriness.
Qin Y, Wang Y, Zhang Y, Jiao Y, Ye J. Qin Y, et al. Ther Adv Hematol. 2024 Mar 13;15:20406207241237606. doi: 10.1177/20406207241237606. eCollection 2024. Ther Adv Hematol. 2024. PMID: 38481948 Free PMC article. - Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels.
Trevisan B, Rodriguez M, Medder H, Lankford S, Combs R, Owen J, Atala A, Porada CD, Almeida-Porada G. Trevisan B, et al. Front Immunol. 2022 Dec 2;13:1070476. doi: 10.3389/fimmu.2022.1070476. eCollection 2022. Front Immunol. 2022. PMID: 36532079 Free PMC article. - Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.
Trendel N, Kruger P, Gaglione S, Nguyen J, Pettmann J, Sontag ED, Dushek O. Trendel N, et al. Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15. Sci Signal. 2021. PMID: 34855472 Free PMC article. - Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
Christen U, Hintermann E. Christen U, et al. Int J Mol Sci. 2016 Dec 1;17(12):2007. doi: 10.3390/ijms17122007. Int J Mol Sci. 2016. PMID: 27916939 Free PMC article. Review. - Malaria and the liver: immunological hide-and-seek or subversion of immunity from within?
Bertolino P, Bowen DG. Bertolino P, et al. Front Microbiol. 2015 Feb 18;6:41. doi: 10.3389/fmicb.2015.00041. eCollection 2015. Front Microbiol. 2015. PMID: 25741320 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials