Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250 - PubMed (original) (raw)
. 1994 Feb 11;263(5148):811-4.
doi: 10.1126/science.8303298.
Affiliations
- PMID: 8303298
- DOI: 10.1126/science.8303298
Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250
E H Wang et al. Science. 1994.
Abstract
The TAFII250 subunit of the human transcription factor IID (TFIID) rescues the temperature-sensitive hamster cell line ts13 and overcomes a G1 arrest. Investigation of the transcriptional properties of ts13 nuclear extracts in vitro showed that activation by the site-specific regulators Sp1 and Gal4VP16 is temperature sensitive in ts13 extracts, whereas basal transcription remains unaffected. This transcriptional defect can be rescued by purified human TFIID or by expression of wild-type TAFII250 in ts13 cells. Expression from the cyclin A but not c-fos promoter is temperature sensitive in these mutant cells. Thus, the mutation in TAFII250 appears to have gene-specific effects that may lead to the ts13 cell cycle phenotype.
Similar articles
- The ts13 mutation in the TAF(II)250 subunit (CCG1) of TFIID directly affects transcription of D-type cyclin genes in cells arrested in G1 at the nonpermissive temperature.
Suzuki-Yagawa Y, Guermah M, Roeder RG. Suzuki-Yagawa Y, et al. Mol Cell Biol. 1997 Jun;17(6):3284-94. doi: 10.1128/MCB.17.6.3284. Mol Cell Biol. 1997. PMID: 9154827 Free PMC article. - TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins.
Wang EH, Zou S, Tjian R. Wang EH, et al. Genes Dev. 1997 Oct 15;11(20):2658-69. doi: 10.1101/gad.11.20.2658. Genes Dev. 1997. PMID: 9334328 Free PMC article. - Herpes simplex virus 1 late gene expression is preferentially inhibited during infection of the TAF250 mutant ts13 cell line.
Dhar S, Weir JP. Dhar S, et al. Virology. 2000 Apr 25;270(1):190-200. doi: 10.1006/viro.2000.0259. Virology. 2000. PMID: 10772991 - Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.
Dunphy EL, Johnson T, Auerbach SS, Wang EH. Dunphy EL, et al. Mol Cell Biol. 2000 Feb;20(4):1134-9. doi: 10.1128/MCB.20.4.1134-1139.2000. Mol Cell Biol. 2000. PMID: 10648598 Free PMC article. - TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.
Hilton TL, Li Y, Dunphy EL, Wang EH. Hilton TL, et al. Mol Cell Biol. 2005 May;25(10):4321-32. doi: 10.1128/MCB.25.10.4321-4332.2005. Mol Cell Biol. 2005. PMID: 15870300 Free PMC article.
Cited by
- Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
Kloet SL, Whiting JL, Gafken P, Ranish J, Wang EH. Kloet SL, et al. Mol Cell Biol. 2012 Aug;32(16):3358-69. doi: 10.1128/MCB.00416-12. Epub 2012 Jun 18. Mol Cell Biol. 2012. PMID: 22711989 Free PMC article. - Derepression of DNA damage-regulated genes requires yeast TAF(II)s.
Li B, Reese JC. Li B, et al. EMBO J. 2000 Aug 1;19(15):4091-100. doi: 10.1093/emboj/19.15.4091. EMBO J. 2000. PMID: 10921889 Free PMC article. - TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations.
Soldatov A, Nabirochkina E, Georgieva S, Belenkaja T, Georgiev P. Soldatov A, et al. Mol Cell Biol. 1999 May;19(5):3769-78. doi: 10.1128/MCB.19.5.3769. Mol Cell Biol. 1999. PMID: 10207100 Free PMC article. - Region of yeast TAF 130 required for TFIID to associate with promoters.
Mencía M, Struhl K. Mencía M, et al. Mol Cell Biol. 2001 Feb;21(4):1145-54. doi: 10.1128/MCB.21.4.1145-1154.2001. Mol Cell Biol. 2001. PMID: 11158301 Free PMC article. - CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.
Kibler KV, Jeang KT. Kibler KV, et al. J Virol. 2001 Mar;75(5):2161-73. doi: 10.1128/JVI.75.5.2161-2173.2001. J Virol. 2001. PMID: 11160720 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources