Effect of side and rate of stimulation on cerebral blood flow changes in motor areas during finger movements in humans - PubMed (original) (raw)

Comparative Study

Effect of side and rate of stimulation on cerebral blood flow changes in motor areas during finger movements in humans

U Sabatini et al. J Cereb Blood Flow Metab. 1993 Jul.

Abstract

We measured, using single photon emission computed tomography, the regional CBF (rCBF) changes in the motor areas of 24 right-handed normal volunteers during the performance of a motor task consisting of sequential finger-to-thumb opposition. Twelve of them performed the task with their right and their left hands consecutively with a fast frequency and large amplitude. The other 12 subjects performed the task with their right hand only at a slow frequency and small amplitude. The contralateral primary sensorimotor areas (S1/M1), supplementary motor area (SMA), and ipsilateral cerebellum were significantly activated during right and left finger movements performed at fast frequency and large amplitude. No significant difference was found between the rCBF changes induced by the right dominant and left nondominant hands. When the task was performed with a slow rate and small amplitude, the SMA was significantly activated while no significant changes were observed in the contralateral S1/M1 or in the ipsilateral cerebellum. These results demonstrate (a) that hand dominance evokes no differences in the activation of the main motor areas and (b) that the frequency and amplitude of the movement have a major effect on the quantitative and qualitative aspect of activation of motor areas in humans.

PubMed Disclaimer

Similar articles

• Regional cerebral blood flow during voluntary arm and hand movements in human subjects.
  Colebatch JG, Deiber MP, Passingham RE, Friston KJ, Frackowiak RS. Colebatch JG, et al. J Neurophysiol. 1991 Jun;65(6):1392-401. doi: 10.1152/jn.1991.65.6.1392. J Neurophysiol. 1991. PMID: 1875248
• Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement.
  Kawashima R, Yamada K, Kinomura S, Yamaguchi T, Matsui H, Yoshioka S, Fukuda H. Kawashima R, et al. Brain Res. 1993 Sep 24;623(1):33-40. doi: 10.1016/0006-8993(93)90006-9. Brain Res. 1993. PMID: 8221091
• Changes in regional cerebral blood flow during self-paced arm and finger movements. A PET study.
  Kawashima R, Itoh H, Ono S, Satoh K, Furumoto S, Gotoh R, Koyama M, Yoshioka S, Takahashi T, Takahashi K, Yanagisawa T, Fukuda H. Kawashima R, et al. Brain Res. 1996 Apr 15;716(1-2):141-8. doi: 10.1016/0006-8993(96)00032-7. Brain Res. 1996. PMID: 8738230 Clinical Trial.
• The functional anatomy of recovery from brain injury.
  Frackowiak RS, Weiller C, Chollet F. Frackowiak RS, et al. Ciba Found Symp. 1991;163:235-44; discussion 244-9. doi: 10.1002/9780470514184.ch14. Ciba Found Symp. 1991. PMID: 1815894 Review.
• Brain regions involved in voluntary movements as revealed by radioisotopic mapping of CBF or CMR-glucose changes.
  Lassen NA, Ingvar DH. Lassen NA, et al. Rev Neurol (Paris). 1990;146(10):620-5. Rev Neurol (Paris). 1990. PMID: 2263825 Review.

Cited by

• Modulation of event-related desynchronization in robot-assisted hand performance: brain oscillatory changes in active, passive and imagined movements.
  Formaggio E, Storti SF, Boscolo Galazzo I, Gandolfi M, Geroin C, Smania N, Spezia L, Waldner A, Fiaschi A, Manganotti P. Formaggio E, et al. J Neuroeng Rehabil. 2013 Feb 26;10:24. doi: 10.1186/1743-0003-10-24. J Neuroeng Rehabil. 2013. PMID: 23442349 Free PMC article.
• Functional and effective connectivity of visuomotor control systems demonstrated using generalized partial least squares and structural equation modeling.
  Lin FH, Agnew JA, Belliveau JW, Zeffiro TA. Lin FH, et al. Hum Brain Mapp. 2009 Jul;30(7):2232-51. doi: 10.1002/hbm.20664. Hum Brain Mapp. 2009. PMID: 19288462 Free PMC article.
• The role of the unaffected hemisphere in motor recovery after stroke.
  Riecker A, Gröschel K, Ackermann H, Schnaudigel S, Kassubek J, Kastrup A. Riecker A, et al. Hum Brain Mapp. 2010 Jul;31(7):1017-29. doi: 10.1002/hbm.20914. Hum Brain Mapp. 2010. PMID: 20091792 Free PMC article.
• Temporal dynamics of ipsilateral and contralateral motor activity during voluntary finger movement.
  Huang MX, Harrington DL, Paulson KM, Weisend MP, Lee RR. Huang MX, et al. Hum Brain Mapp. 2004 Sep;23(1):26-39. doi: 10.1002/hbm.20038. Hum Brain Mapp. 2004. PMID: 15281139 Free PMC article.
• Encoding of speed and direction of movement in the human supplementary motor area.
  Tankus A, Yeshurun Y, Flash T, Fried I. Tankus A, et al. J Neurosurg. 2009 Jun;110(6):1304-16. doi: 10.3171/2008.10.JNS08466. J Neurosurg. 2009. PMID: 19231930 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon