Environmental modulation of the autonomy of cytotoxic T lymphocytes - PubMed (original) (raw)
Environmental modulation of the autonomy of cytotoxic T lymphocytes
H Bodmer et al. Eur J Immunol. 1993 Jul.
Abstract
The extent to which one compartment of the immune system depends on another for efficient function is important to establish to fully comprehend disease phenotypes arising from selective immunodeficiency. Just how much the major histocompatibility complex class I-restricted cytotoxic T cell responses depend on class II-restricted T cell help has been controversial. Using the influenza A virus system, we show that mice unable to make class II-restricted T cell responses due to an engineered defect in class II molecule expression are able to mount virtually normal cytotoxic responses when bred under specific-pathogen-free conditions. However, when exposed to the more diverse environmental challenges of a conventional breeding facility, a situation that more closely parallels immunodeficient states in man, they show impaired cytotoxic responses.
Similar articles
- Comparison of class I- and II-restricted T cell recognition of the identical peptide.
Perkins DL, Berriz G, Wang YS, Smith JA, Gefter ML. Perkins DL, et al. Eur J Immunol. 1991 Nov;21(11):2781-9. doi: 10.1002/eji.1830211120. Eur J Immunol. 1991. PMID: 1718759 - Identification of overlapping class I and class II H-2d-restricted T cell determinants of influenza virus N1 neuraminidase that require infectious virus for presentation.
Wysocka M, Eisenlohr LC, Otvos L Jr, Horowitz D, Yewdell JW, Bennink JR, Hackett CJ. Wysocka M, et al. Virology. 1994 May 15;201(1):86-94. doi: 10.1006/viro.1994.1268. Virology. 1994. PMID: 7513927 - Cytotoxic T cells in influenza infection.
Askonas BA, Taylor PM, Esquivel F. Askonas BA, et al. Ann N Y Acad Sci. 1988;532:230-7. doi: 10.1111/j.1749-6632.1988.tb36342.x. Ann N Y Acad Sci. 1988. PMID: 2845845 Review. No abstract available. - Specialized function of the nonclassical MHC class I molecule Hmt: a specific receptor for N-formylated peptides.
Shawar SM, Rodgers JR, Cook RG, Rich RR. Shawar SM, et al. Immunol Res. 1991;10(3-4):365-75. doi: 10.1007/BF02919723. Immunol Res. 1991. PMID: 1835490 Review. No abstract available.
Cited by
- Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection.
Gopal R, Marinelli MA, Alcorn JF. Gopal R, et al. Front Immunol. 2020 Oct 22;11:570681. doi: 10.3389/fimmu.2020.570681. eCollection 2020. Front Immunol. 2020. PMID: 33193350 Free PMC article. Review. - Engineering universal cells that evade immune detection.
Lanza R, Russell DW, Nagy A. Lanza R, et al. Nat Rev Immunol. 2019 Dec;19(12):723-733. doi: 10.1038/s41577-019-0200-1. Epub 2019 Aug 15. Nat Rev Immunol. 2019. PMID: 31417198 Review. - MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.
Alsharifi M, Koskinen A, Wijesundara DK, Bettadapura J, Müllbacher A. Alsharifi M, et al. PLoS One. 2013 Jun 28;8(6):e68458. doi: 10.1371/journal.pone.0068458. Print 2013. PLoS One. 2013. PMID: 23840854 Free PMC article. - Hallmarks of CD4 T cell immunity against influenza.
McKinstry KK, Strutt TM, Swain SL. McKinstry KK, et al. J Intern Med. 2011 May;269(5):507-18. doi: 10.1111/j.1365-2796.2011.02367.x. Epub 2011 Mar 25. J Intern Med. 2011. PMID: 21362069 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources