Anticipation in bipolar affective disorder - PubMed (original) (raw)

Anticipation in bipolar affective disorder

M G McInnis et al. Am J Hum Genet. 1993 Aug.

Abstract

Anticipation refers to the increase in disease severity or decrease in age at onset in succeeding generations. This phenomenon, formerly ascribed to observation biases, correlates with the expansion of trinucleotide repeat sequences (TNRs) in some disorders. If present in bipolar affective disorder (BPAD), anticipation could provide clues to its genetic etiology. We compared age at onset and disease severity between two generations of 34 unilineal families ascertained for a genetic linkage study of BPAD. Life-table analyses showed a significant decrease in survival to first mania or depression from the first to the second generation (P < .001). Intergenerational pairwise comparisons showed both a significantly earlier age at onset (P < .001) and a significantly increased disease severity (P < .001) in the second generation. This difference was significant under each of four data-sampling schemes which excluded probands in the second generation. The second generation experienced onset 8.9-13.5 years earlier and illness 1.8-3.4 times more severe than did the first generation. In additional analyses, drug abuse, deaths of affected individuals prior to interview, decreased fertility, censoring of age at onset, and the cohort effect did not affect our results. We conclude that genetic anticipation occurs in this sample of unilineal BPAD families. These findings may implicate genes with expanding TNRs in the genetic etiology of BPAD.

PubMed Disclaimer

Comment in

• Regression to the mean does not exclude anticipation and unstable DNA disease.
  Petronis A, Sherrington R, Kennedy JL. Petronis A, et al. Am J Hum Genet. 1994 Sep;55(3):589-92. Am J Hum Genet. 1994. PMID: 8080001 Free PMC article. No abstract available.
• Anticipation in mental illness.
  Asherson P, Owen M. Asherson P, et al. Am J Hum Genet. 1994 Feb;54(2):386-7. Am J Hum Genet. 1994. PMID: 8304354 Free PMC article. No abstract available.

Similar articles

• Anticipation in unipolar affective disorder.
  Engström C, Thornlund AS, Johansson EL, Långström M, Chotai J, Adolfsson R, Nylander PO. Engström C, et al. J Affect Disord. 1995 Oct 9;35(1-2):31-40. doi: 10.1016/0165-0327(95)00035-l. J Affect Disord. 1995. PMID: 8557885
• Anticipation in Swedish families with bipolar affective disorder.
  Nylander PO, Engström C, Chotai J, Wahlström J, Adolfsson R. Nylander PO, et al. J Med Genet. 1994 Sep;31(9):686-9. doi: 10.1136/jmg.31.9.686. J Med Genet. 1994. PMID: 7815436 Free PMC article.
• Expanded trinucleotide CAG repeats in families with bipolar affective disorder.
  Mendlewicz J, Lindbald K, Souery D, Mahieu B, Nylander PO, De Bruyn A, Zander C, Engström C, Adolfsson R, Van Broeckhoven C, Schalling M, Lipp O. Mendlewicz J, et al. Biol Psychiatry. 1997 Dec 15;42(12):1115-22. doi: 10.1016/s0006-3223(97)00395-8. Biol Psychiatry. 1997. PMID: 9426881 Clinical Trial.
• The unstable trinucleotide repeat story of major psychosis.
  Vincent JB, Paterson AD, Strong E, Petronis A, Kennedy JL. Vincent JB, et al. Am J Med Genet. 2000 Spring;97(1):77-97. doi: 10.1002/(sici)1096-8628(200021)97:1<77::aid-ajmg11>3.0.co;2-3. Am J Med Genet. 2000. PMID: 10813808 Review.
• Anticipation and repeat expansion in bipolar disorder.
  O'Donovan M, Jones I, Craddock N. O'Donovan M, et al. Am J Med Genet C Semin Med Genet. 2003 Nov 15;123C(1):10-7. doi: 10.1002/ajmg.c.20009. Am J Med Genet C Semin Med Genet. 2003. PMID: 14601032 Review.

Cited by

• Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.
  Singh MK, Gorelik AJ, Stave C, Gotlib IH. Singh MK, et al. Mol Psychiatry. 2024 Mar;29(3):553-565. doi: 10.1038/s41380-023-02347-x. Epub 2023 Dec 15. Mol Psychiatry. 2024. PMID: 38102485
• FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders.
  Deshmukh AL, Porro A, Mohiuddin M, Lanni S, Panigrahi GB, Caron MC, Masson JY, Sartori AA, Pearson CE. Deshmukh AL, et al. J Huntingtons Dis. 2021;10(1):95-122. doi: 10.3233/JHD-200448. J Huntingtons Dis. 2021. PMID: 33579867 Free PMC article. Review.
• The Contribution of Somatic Expansion of the CAG Repeat to Symptomatic Development in Huntington's Disease: A Historical Perspective.
  Monckton DG. Monckton DG. J Huntingtons Dis. 2021;10(1):7-33. doi: 10.3233/JHD-200429. J Huntingtons Dis. 2021. PMID: 33579863 Free PMC article. Review.
• Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia.
  Mojarad BA, Yin Y, Manshaei R, Backstrom I, Costain G, Heung T, Merico D, Marshall CR, Bassett AS, Yuen RKC. Mojarad BA, et al. Transl Psychiatry. 2021 Feb 1;11(1):84. doi: 10.1038/s41398-021-01211-2. Transl Psychiatry. 2021. PMID: 33526774 Free PMC article.
• Role of telomere shortening in anticipation of inflammatory bowel disease.
  Truta B, Wohler E, Sobreira N, Datta LW, Brant SR. Truta B, et al. World J Gastrointest Pharmacol Ther. 2020 Sep 8;11(4):69-78. doi: 10.4292/wjgpt.v11.i4.69. World J Gastrointest Pharmacol Ther. 2020. PMID: 32953227 Free PMC article.

References

1. 1. Arch Gen Psychiatry. 1987 Apr;44(4):314-9 - PubMed
2. 1. Am J Hum Genet. 1992 Jul;51(1):10-6 - PubMed
3. 1. Br J Psychiatry. 1977 Apr;130:330-51 - PubMed
4. 1. Nature. 1977 Jul 28;268(5618):327-9 - PubMed
5. 1. Arch Gen Psychiatry. 1978 Jul;35(7):837-44 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information