Adhesion molecule expression on cerebrospinal fluid T lymphocytes: evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls - PubMed (original) (raw)
Adhesion molecule expression on cerebrospinal fluid T lymphocytes: evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls
A Svenningsson et al. Ann Neurol. 1993 Aug.
Abstract
The expression of T-cell surface antigens was investigated in the cerebrospinal fluid (CSF) and peripheral blood of 11 patients with multiple sclerosis, 6 patients with aseptic meningitis, and 16 healthy subjects. A panel of monoclonal antibodies to adhesion and activation proteins was used in combination with an anti-CD3 antibody in dual-color flow cytometry. The problem of low cell numbers in the CSF from normal individuals was overcome by use of a modified staining procedure in microtiter plates, enabling analysis of as few as 5,000 cells. The majority of T cells in the CSF of the three patient groups exhibited the phenotype of memory cells (CD45RO+). CSF T cells also expressed significantly higher levels of several adhesion and activation molecules, including very late activation (VLA) antigens 3 through 6, lymphocyte function-associated (LFA) antigen 1, LFA-3, CD2, CD26, and CD44. Comparison between the different categories revealed that peripheral blood T cells from patients with multiple sclerosis expressed significantly lower amounts of the VLA integrins 4 and 5 as well as their common beta subunit CD29, compared with normal control subjects. No differences between patients with multiple sclerosis and control subjects could, however, be seen regarding the distribution of memory/naive cells or CD4+/CD8+ cells in peripheral blood. Our data support a hypothesis that memory T cells with a high expression of several adhesion molecules are selectively recruited to the central nervous system compartment, under both pathological and normal conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis.
Stüve O, Marra CM, Bar-Or A, Niino M, Cravens PD, Cepok S, Frohman EM, Phillips JT, Arendt G, Jerome KR, Cook L, Grand'Maison F, Hemmer B, Monson NL, Racke MK. Stüve O, et al. Arch Neurol. 2006 Oct;63(10):1383-7. doi: 10.1001/archneur.63.10.1383. Arch Neurol. 2006. PMID: 17030653 Clinical Trial. - Immune surveillance in multiple sclerosis patients treated with natalizumab.
Stüve O, Marra CM, Jerome KR, Cook L, Cravens PD, Cepok S, Frohman EM, Phillips JT, Arendt G, Hemmer B, Monson NL, Racke MK. Stüve O, et al. Ann Neurol. 2006 May;59(5):743-7. doi: 10.1002/ana.20858. Ann Neurol. 2006. PMID: 16634029 - Multiple sclerosis: activated cells in cerebrospinal fluid in acute exacerbations.
Noronha A, Richman DP, Arnason BG. Noronha A, et al. Ann Neurol. 1985 Dec;18(6):722-5. doi: 10.1002/ana.410180617. Ann Neurol. 1985. PMID: 3841270 - Immunopathogenesis of vernal keratoconjunctivitis.
Abu el-Asrar AM, Geboes K, Tabbara KF, van den Oord JJ, Missotten L. Abu el-Asrar AM, et al. Bull Soc Belge Ophtalmol. 1996;261:15-24. Bull Soc Belge Ophtalmol. 1996. PMID: 9009358 Review. - Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients.
Giacomelli R, Matucci-Cerinic M, Cipriani P, Ghersetich I, Lattanzio R, Pavan A, Pignone A, Cagnoni ML, Lotti T, Tonietti G. Giacomelli R, et al. Arthritis Rheum. 1998 Feb;41(2):327-34. doi: 10.1002/1529-0131(199802)41:2<327::AID-ART17>3.0.CO;2-S. Arthritis Rheum. 1998. PMID: 9485091 Review.
Cited by
- CD3+CD56+ and CD3-CD56+ lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C.
de Almeida SM, Beltrame MP, Tang B, Rotta I, Justus JLP, Schluga Y, da Rocha MT, Martins E, Liao A, Abramson I, Vaida F, Schrier R, Ellis RJ. de Almeida SM, et al. J Neuroimmunol. 2023 Apr 15;377:578067. doi: 10.1016/j.jneuroim.2023.578067. Epub 2023 Mar 17. J Neuroimmunol. 2023. PMID: 36965365 Free PMC article. - Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.
Piehl N, van Olst L, Ramakrishnan A, Teregulova V, Simonton B, Zhang Z, Tapp E, Channappa D, Oh H, Losada PM, Rutledge J, Trelle AN, Mormino EC, Elahi F, Galasko DR, Henderson VW, Wagner AD, Wyss-Coray T, Gate D. Piehl N, et al. Cell. 2022 Dec 22;185(26):5028-5039.e13. doi: 10.1016/j.cell.2022.11.019. Epub 2022 Dec 13. Cell. 2022. PMID: 36516855 Free PMC article. - Immunological defense of CNS barriers against infections.
Ampie L, McGavern DB. Ampie L, et al. Immunity. 2022 May 10;55(5):781-799. doi: 10.1016/j.immuni.2022.04.012. Immunity. 2022. PMID: 35545028 Free PMC article. Review. - CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis.
Hrastelj J, Andrews R, Loveless S, Morgan J, Bishop SM, Bray NJ, Williams NM, Robertson NP. Hrastelj J, et al. Brain Commun. 2021 Jul 13;3(3):fcab155. doi: 10.1093/braincomms/fcab155. eCollection 2021. Brain Commun. 2021. PMID: 34761221 Free PMC article. - Dementia-associated changes of immune cell composition within the cerebrospinal fluid.
Busse S, Hoffmann J, Michler E, Hartig R, Frodl T, Busse M. Busse S, et al. Brain Behav Immun Health. 2021 Apr 20;14:100218. doi: 10.1016/j.bbih.2021.100218. eCollection 2021 Jul. Brain Behav Immun Health. 2021. PMID: 34589754 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous