The effects of chronic prenatal exposure to nicotine on the behavior of guinea pigs (Cavia porcellus) - PubMed (original) (raw)

The effects of chronic prenatal exposure to nicotine on the behavior of guinea pigs (Cavia porcellus)

J M Johns et al. J Gen Psychol. 1993 Jan.

Abstract

Three groups of 15 offspring from guinea pig dams were injected twice daily throughout gestation with one of three doses (0.5, 1.5 or 2.5 mg/kg) of nicotine-hydrogen tartrate. These offspring and 15 saline-exposed offspring were tested on several behavioral measures. Offspring of nicotine-treated dams had significantly lower rates of spontaneous alternation as neonates. The 1.5 and 2.5 mg/kg nicotine-exposed offspring also alternated less at puberty than control offspring and would not enter an unfamiliar stimulus alley that a majority of controls entered. Nicotine offspring, as adults, performed significantly poorer than their controls on errors and trials to criterion on a discrimination and reversal task. Prenatal nicotine treatment resulted in performance deficits on both learned and innate behavioral measures throughout development and adulthood.

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