Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes - PubMed (original) (raw)
Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes
L Bondesson et al. Immunopharmacol Immunotoxicol. 1993 Mar-Jun.
Abstract
The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10(-10)mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10(-4)mol/l, ketanserin at 10(-4) and 10(-8)-10(-10)mol/l and methiotepine at 10(-4) and 10(-6)-10(-8)mol/l. No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.
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