A retinoblastoma-binding protein related to a negative regulator of Ras in yeast - PubMed (original) (raw)
. 1993 Aug 12;364(6438):648-52.
doi: 10.1038/364648a0.
Affiliations
- PMID: 8350924
- DOI: 10.1038/364648a0
A retinoblastoma-binding protein related to a negative regulator of Ras in yeast
Y W Qian et al. Nature. 1993.
Abstract
The growth suppression function of the retinoblastoma protein (Rb) is though to be mediated by Rb binding to cellular proteins. p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complementary DNA (RbAp48) encoding p48. Complex formation between p48 and Rb occurs in vitro and in vivo, and apparently involves direct interaction between the proteins. Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp48 share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2Val19 strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb.
Similar articles
- Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.
Qian YW, Lee EY. Qian YW, et al. J Biol Chem. 1995 Oct 27;270(43):25507-13. doi: 10.1074/jbc.270.43.25507. J Biol Chem. 1995. PMID: 7503932 - MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae.
Ruggieri R, Tanaka K, Nakafuku M, Kaziro Y, Toh-e A, Matsumoto K. Ruggieri R, et al. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8778-82. doi: 10.1073/pnas.86.22.8778. Proc Natl Acad Sci U S A. 1989. PMID: 2554329 Free PMC article. - A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals.
Ach RA, Taranto P, Gruissem W. Ach RA, et al. Plant Cell. 1997 Sep;9(9):1595-606. doi: 10.1105/tpc.9.9.1595. Plant Cell. 1997. PMID: 9338962 Free PMC article. - RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.
Nicolas E, Morales V, Magnaghi-Jaulin L, Harel-Bellan A, Richard-Foy H, Trouche D. Nicolas E, et al. J Biol Chem. 2000 Mar 31;275(13):9797-804. doi: 10.1074/jbc.275.13.9797. J Biol Chem. 2000. PMID: 10734134 - The TOR signalling pathway and growth control in yeast.
Hall MN. Hall MN. Biochem Soc Trans. 1996 Feb;24(1):234-9. doi: 10.1042/bst0240234. Biochem Soc Trans. 1996. PMID: 8674674 Review. No abstract available.
Cited by
- RBBP4: A novel diagnostic and prognostic biomarker for non-small-cell lung cancer correlated with autophagic cell death.
Zhan Y, Zhang Z, Yin A, Su X, Tang N, Chen Y, Zhang Z, Chen W, Wang J, Wang W. Zhan Y, et al. Cancer Med. 2024 Aug;13(15):e70090. doi: 10.1002/cam4.70090. Cancer Med. 2024. PMID: 39109577 Free PMC article. - Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).
Zhan Y, Yin A, Su X, Tang N, Zhang Z, Chen Y, Wang W, Wang J. Zhan Y, et al. Int J Mol Med. 2024 May;53(5):48. doi: 10.3892/ijmm.2024.5372. Epub 2024 Apr 5. Int J Mol Med. 2024. PMID: 38577935 Free PMC article. Review. - Unveiling the molecular structure and role of RBBP4/7: implications for epigenetic regulation and cancer research.
Cai L, Liu B, Cao Y, Sun T, Li Y. Cai L, et al. Front Mol Biosci. 2023 Nov 13;10:1276612. doi: 10.3389/fmolb.2023.1276612. eCollection 2023. Front Mol Biosci. 2023. PMID: 38028543 Free PMC article. Review. - Identifying pathogenicity-related genes in the pathogen Colletotrichum magnum causing watermelon anthracnose disease via T-DNA insertion mutagenesis.
Guo Z, Wu H, Peng B, Kang B, Liu L, Luo C, Gu Q. Guo Z, et al. Front Microbiol. 2023 Jul 20;14:1220116. doi: 10.3389/fmicb.2023.1220116. eCollection 2023. Front Microbiol. 2023. PMID: 37547676 Free PMC article. - Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex.
Yue Y, Yang WS, Zhang L, Liu CP, Xu RM. Yue Y, et al. Genes Dev. 2022 Apr 1;36(7-8):408-413. doi: 10.1101/gad.349099.121. Epub 2022 Apr 7. Genes Dev. 2022. PMID: 35393344 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous