Localization of E2A mRNA expression in developing and adult rat tissues - PubMed (original) (raw)
Localization of E2A mRNA expression in developing and adult rat tissues
V J Roberts et al. Proc Natl Acad Sci U S A. 1993.
Abstract
E2A helix-loop-helix proteins are involved in the control of various developmental pathways. We show here by in situ hybridization that E2A transcripts are present in most embryonic and adult tissues. However, no E2A expression is detectable in heart and nonproliferative regions of the brain and spinal cord. Highest levels of E2A expression are found in the ependyma cell layer surrounding the cerebral ventricles in the embryonic rat brain. In addition, in the embryo, E2A transcripts were found in secretory cells of the pancreas, the bronchial tubes of the lung, glomeruli of the kidney, and the lining of the stomach. Interestingly, high levels of E2A transcripts are selectively found in the germinal center of the lymphatic nodules in the adult rat spleen. Thus, E2A, like its Drosophila homolog daughterless, is expressed in most tissues. The most notable feature of the E2A expression pattern is its high levels of expression in some areas of rapid cell proliferation and differentiation and in certain epithelial cell types.
Similar articles
- The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation.
Voronova AF, Lee F. Voronova AF, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5952-6. doi: 10.1073/pnas.91.13.5952. Proc Natl Acad Sci U S A. 1994. PMID: 8016095 Free PMC article. - Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.
Aronheim A, Shiran R, Rosen A, Walker MD. Aronheim A, et al. Nucleic Acids Res. 1993 Apr 11;21(7):1601-6. doi: 10.1093/nar/21.7.1601. Nucleic Acids Res. 1993. PMID: 8479911 Free PMC article. - Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis.
Cameron VA, Nishimura E, Mathews LS, Lewis KA, Sawchenko PE, Vale WW. Cameron VA, et al. Endocrinology. 1994 Feb;134(2):799-808. doi: 10.1210/endo.134.2.8299574. Endocrinology. 1994. PMID: 8299574 - Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis.
Roberts VJ, Barth SL. Roberts VJ, et al. Endocrinology. 1994 Feb;134(2):914-23. doi: 10.1210/endo.134.2.8299586. Endocrinology. 1994. PMID: 8299586 - Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions.
Rosen B, Beddington RS. Rosen B, et al. Trends Genet. 1993 May;9(5):162-7. doi: 10.1016/0168-9525(93)90162-b. Trends Genet. 1993. PMID: 8337752 Review.
Cited by
- Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.
Talley MJ, Nardini D, Ehrman LA, Lu QR, Waclaw RR. Talley MJ, et al. Neural Dev. 2023 Sep 8;18(1):5. doi: 10.1186/s13064-023-00173-z. Neural Dev. 2023. PMID: 37684687 Free PMC article. - Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.
Torres-Machorro AL. Torres-Machorro AL. Int J Mol Sci. 2021 Nov 28;22(23):12855. doi: 10.3390/ijms222312855. Int J Mol Sci. 2021. PMID: 34884664 Free PMC article. Review. - Characterization of the bHLH family of transcriptional regulators in the acoel S. roscoffensis and their putative role in neurogenesis.
Perea-Atienza E, Sprecher SG, Martínez P. Perea-Atienza E, et al. Evodevo. 2018 Mar 29;9:8. doi: 10.1186/s13227-018-0097-y. eCollection 2018. Evodevo. 2018. PMID: 29610658 Free PMC article. - Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells.
Patel D, Chinaranagari S, Chaudhary J. Patel D, et al. Am J Cancer Res. 2015 Oct 15;5(11):3407-21. eCollection 2015. Am J Cancer Res. 2015. PMID: 26807321 Free PMC article. - A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis.
Hirano T, Murakami T, Ono H, Sakurai A, Tominaga T, Takahashi T, Nagai K, Doi T, Abe H. Hirano T, et al. PLoS One. 2015 Jul 24;10(7):e0133205. doi: 10.1371/journal.pone.0133205. eCollection 2015. PLoS One. 2015. PMID: 26208142 Free PMC article.
References
- Cell. 1991 Jan 25;64(2):459-70 - PubMed
- Mol Cell Biol. 1992 Mar;12(3):1031-42 - PubMed
- Nature. 1985 Feb 28-Mar 6;313(6005):798-801 - PubMed
- Cell. 1987 Dec 24;51(6):987-1000 - PubMed
- Mol Cell Biol. 1988 Jun;8(6):2620-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources