Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum - PubMed (original) (raw)
Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum
J D Elsworth et al. Neurochem Int. 1993 Jul.
Erratum in
- Neurochem Int 1995 Apr;26(4):I
Abstract
Behavioral studies have indicated that the reinforcing effects of cocaine are dependent on inhibition of dopamine uptake in nucleus accumbens and prefrontal cortex. As it has been suggested that dopamine uptake and cocaine-inhibition of dopamine uptake may differ in nucleus accumbens, prefrontal cortex and striatum, we have further characterized dopamine uptake and its susceptibility to inhibition in these three regions. Dopamine uptake was resolved into two processes, which accounts for some of the apparent reported regional differences in sensitivity of dopamine to inhibition by cocaine. One, which is probably associated with uptake into dopaminergic terminals, was sensitive to 6-hydroxydopamine lesions, cocaine, GBR 12909 or ouabain and was dependent on temperature and sodium ion concentration; this was responsible for most of the observed uptake in tissue from striatum and nucleus accumbens, but not from prefrontal cortex. There appeared to be no regional difference in susceptibility of this mode of dopamine uptake to either cocaine or GBR 12909. The other type of dopamine uptake, which represented a significant proportion of the total in prefrontal cortex, but not in striatum or nucleus accumbens, was relatively insensitive to cocaine, GBR 12909 and ouabain and was dependent on temperature, but not sodium ion concentration. In addition, the cocaine-insensitive dopamine uptake was more sensitive to inhibition by dopamine than serotonin, but did not distinguish between dopamine and norepinephrine. The occurrence of cocaine-sensitive dopamine uptake in all examined regions and its equal sensitivity to cocaine and GBR 12909 is consistent with the involvement of nucleus accumbens and/or prefrontal cortex in the reinforcing effects of cocaine.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats.
Masserano JM, Venable D, Wyatt RJ. Masserano JM, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):133-41. J Pharmacol Exp Ther. 1994. PMID: 8035309 - Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens.
Berger P, Elsworth JD, Arroyo J, Roth RH. Berger P, et al. Eur J Pharmacol. 1990 Feb 20;177(1-2):91-4. doi: 10.1016/0014-2999(90)90554-j. Eur J Pharmacol. 1990. PMID: 1967129 - In vivo assessment of dopamine uptake in rat medial prefrontal cortex: comparison with dorsal striatum and nucleus accumbens.
Cass WA, Gerhardt GA. Cass WA, et al. J Neurochem. 1995 Jul;65(1):201-7. doi: 10.1046/j.1471-4159.1995.65010201.x. J Neurochem. 1995. PMID: 7790861 - Aversion hot spots in the dopamine system.
Verharen JPH, Zhu Y, Lammel S. Verharen JPH, et al. Curr Opin Neurobiol. 2020 Oct;64:46-52. doi: 10.1016/j.conb.2020.02.002. Epub 2020 Mar 5. Curr Opin Neurobiol. 2020. PMID: 32146296 Free PMC article. Review.
Cited by
- On the Role of Cannabinoid CB1- and μ-Opioid Receptors in Motor Impulsivity.
Wiskerke J, van Mourik Y, Schetters D, Schoffelmeer AN, Pattij T. Wiskerke J, et al. Front Pharmacol. 2012 Jun 11;3:108. doi: 10.3389/fphar.2012.00108. eCollection 2012. Front Pharmacol. 2012. PMID: 22701425 Free PMC article. - The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents.
Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M. Dutta AK, et al. Eur J Pharmacol. 2011 Dec 5;671(1-3):39-44. doi: 10.1016/j.ejphar.2011.09.162. Epub 2011 Sep 24. Eur J Pharmacol. 2011. PMID: 21963455 Free PMC article. - Effects of cocaine on monoamine uptake as measured ex vivo.
Wang Z, Ordway GA, Woolverton W. Wang Z, et al. Neurosci Lett. 2007 Feb 21;413(3):191-5. doi: 10.1016/j.neulet.2006.11.041. Epub 2006 Dec 13. Neurosci Lett. 2007. PMID: 17169488 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials