Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme - PubMed (original) (raw)

Clinical Trial

Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme

J Little et al. Br J Cancer. 1993 Jan.

Free PMC article

Abstract

Diets high in animal fat and protein and low in fibre and calcium are thought to be factors in the etiology of colorectal cancer. Intakes of these nutrients were determined in three groups participating in a randomised trial of faecal occult blood (FOB) screening. A diet history was obtained by interview from 147 patients with colorectal adenomas, 153 age and sex matched FOB-negative controls (a) and 176 FOB-positive controls without colorectal neoplasia (b). Unconditional logistic regression was used to estimate relative risks (RR) and 95% confidence limits (increases) adjusted for age, sex and social class. After adjustment for total energy intake, no associations were found with total, saturated or mono-unsaturated fat, or calcium intake. For total fibre intake there were non-linear relationships with both control groups with the crude RR for highest quintiles of total fibre intake compared to the lowest being 0.6, although this pattern was no longer apparent after adjustment for energy intake with group (a). In comparison with group (b) cereal fibre intake showed a more consistent inverse relationship with adenoma prevalence with the RR for ascending quintiles of intake being 1.0, 0.7 (0.3-1.6), 0.5 (0.3-1.1), 0.7 (0.4-1.4) and 0.3 (0.1-0.6) (trend chi 2 = 8.80, p = 0.003). In comparison with group (a), the adjusted RR for the highest quintile of cereal fibre intake compared with the lowest was 0.6, but no clear trend was apparent. There was an unexpected positive relationship between adenomas and polyunsaturated fat intake with the RR for having an adenoma being 1.0, 2.8 (1.3-6.1), 1.6 (0.7-3.4), 3.5 (1.6-7.5) and 2.3 (1.1-5.0) for ascending quintiles of polyunsaturated fat intakes (trend chi 2 = 4.8, P = 0.03) in comparison with group (a) only. Our data, while providing no support for the role of dietary animal fat or protein, do support the protective role of dietary cereal fibre in the etiology of colorectal adenomas.

PubMed Disclaimer

Similar articles

• Colorectal adenomas and energy intake, body size and physical activity: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
  Little J, Logan RF, Hawtin PG, Hardcastle JD, Turner ID. Little J, et al. Br J Cancer. 1993 Jan;67(1):172-6. doi: 10.1038/bjc.1993.30. Br J Cancer. 1993. PMID: 8427777 Free PMC article.
• Colorectal adenomas and diet: a case-control study. Colorectal Adenoma Study Group.
  Breuer-Katschinski B, Nemes K, Marr A, Rump B, Leiendecker B, Breuer N, Goebell H; Colorectal Adenoma Study Group. Breuer-Katschinski B, et al. Dig Dis Sci. 2001 Jan;46(1):86-95. doi: 10.1023/a:1005519920643. Dig Dis Sci. 2001. PMID: 11270799
• Diet and risk of colorectal adenomas: macronutrients, cholesterol, and fiber.
  Sandler RS, Lyles CM, Peipins LA, McAuliffe CA, Woosley JT, Kupper LL. Sandler RS, et al. J Natl Cancer Inst. 1993 Jun 2;85(11):884-91. doi: 10.1093/jnci/85.11.884. J Natl Cancer Inst. 1993. PMID: 8388061
• Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies.
  Kampman E, Giovannucci E, van 't Veer P, Rimm E, Stampfer MJ, Colditz GA, Kok FJ, Willett WC. Kampman E, et al. Am J Epidemiol. 1994 Jan 1;139(1):16-29. doi: 10.1093/oxfordjournals.aje.a116931. Am J Epidemiol. 1994. PMID: 8296771 Review.
• Dietary epidemiology of colon cancer.
  Vogel VG, McPherson RS. Vogel VG, et al. Hematol Oncol Clin North Am. 1989 Mar;3(1):35-63. Hematol Oncol Clin North Am. 1989. PMID: 2537285 Review.

Cited by

• Colorectal adenomas and energy intake, body size and physical activity: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
  Little J, Logan RF, Hawtin PG, Hardcastle JD, Turner ID. Little J, et al. Br J Cancer. 1993 Jan;67(1):172-6. doi: 10.1038/bjc.1993.30. Br J Cancer. 1993. PMID: 8427777 Free PMC article.
• Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis.
  Nucci D, Fatigoni C, Salvatori T, Nardi M, Realdon S, Gianfredi V. Nucci D, et al. Int J Environ Res Public Health. 2021 Apr 15;18(8):4168. doi: 10.3390/ijerph18084168. Int J Environ Res Public Health. 2021. PMID: 33920845 Free PMC article. Review.
• Colorectal adenomas and diet: a case-control study. Colorectal Adenoma Study Group.
  Breuer-Katschinski B, Nemes K, Marr A, Rump B, Leiendecker B, Breuer N, Goebell H; Colorectal Adenoma Study Group. Breuer-Katschinski B, et al. Dig Dis Sci. 2001 Jan;46(1):86-95. doi: 10.1023/a:1005519920643. Dig Dis Sci. 2001. PMID: 11270799
• Carotenoid intake and risk of colorectal adenomas in a cohort of male health professionals.
  Jung S, Wu K, Giovannucci E, Spiegelman D, Willett WC, Smith-Warner SA. Jung S, et al. Cancer Causes Control. 2013 Apr;24(4):705-17. doi: 10.1007/s10552-013-0151-y. Epub 2013 Feb 1. Cancer Causes Control. 2013. PMID: 23371557 Free PMC article.
• Nutrition and colorectal cancer.
  Potter JD. Potter JD. Cancer Causes Control. 1996 Jan;7(1):127-46. doi: 10.1007/BF00115644. Cancer Causes Control. 1996. PMID: 8850441 Review.

References

1. 1. Gut. 1992 Feb;33(2):259-63 - PubMed
2. 1. J Natl Cancer Inst. 1992 Jan 15;84(2):91-8 - PubMed
3. 1. Cancer. 1971 Jul;28(1):3-13 - PubMed
4. 1. Br J Cancer. 1973 Feb;27(2):167-72 - PubMed
5. 1. Z Gastroenterol. 1980 Jan;18(1):30-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Nature Publishing Group
  • PubMed Central

• Medical

  • MedlinePlus Health Information