Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders - PubMed (original) (raw)
Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders
J W Tervaert et al. Ann Rheum Dis. 1993 Feb.
Abstract
Antineutrophil cytoplasmic antibodies (ANCAs) constitute a new class of autoantibodies that seem to recognise myeloid lysosomal enzymes. The occurrence of ANCAs with specificity for human leucocyte elastase (HLE) was assessed in serum samples that were routinely submitted for ANCA determination. During a study period of more than six years anti-HLE was found in only six out of 1102 serum samples that produced a perinuclear or an atypical cytoplasmic staining pattern on ethanol fixed granulocytes. These six serum samples were from four patients with a clinical diagnosis of Wegener's granulomatosis but without a definite histological diagnosis, one patient with systemic vasculitis, and one patient with Cogan's syndrome. To further evaluate the prevalence of anti-HLE we tested 315 serum samples from patients with different forms of vasculitis and related disorders. Anti-HLE was detected in two patients only. Thus autoantibodies to HLE are rarely found in serum samples from patients with vasculitic or related disorders.
Similar articles
- Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
Fienberg R, Mark EJ, Goodman M, McCluskey RT, Niles JL. Fienberg R, et al. Hum Pathol. 1993 Feb;24(2):160-8. doi: 10.1016/0046-8177(93)90295-r. Hum Pathol. 1993. PMID: 8381764 - Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA): clinical significance and relation to antibodies against myeloid lysosomal enzymes.
Tervaert JW, Mulder AH, Kallenberg CG. Tervaert JW, et al. Adv Exp Med Biol. 1993;336:253-6. doi: 10.1007/978-1-4757-9182-2_37. Adv Exp Med Biol. 1993. PMID: 8296614 - Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and other diseases: clinical issues.
Galperin C, Hoffman GS. Galperin C, et al. Cleve Clin J Med. 1994 Nov-Dec;61(6):416-27. doi: 10.3949/ccjm.61.6.416. Cleve Clin J Med. 1994. PMID: 7828332 Review. - Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis.
Tervaert JW, Goldschmeding R, Elema JD, van der Giessen M, Huitema MG, van der Hem GK, The TH, von dem Borne AE, Kallenberg CG. Tervaert JW, et al. Kidney Int. 1990 Feb;37(2):799-806. doi: 10.1038/ki.1990.48. Kidney Int. 1990. PMID: 2155342 Review.
Cited by
- Antineutrophil cytoplasmic antibody-negative granulomatosis with polyangiitis localized to the lungs.
Ohteru Y, Hamada K, Oishi K, Suizu J, Harada M, Murakawa K, Chikumoto A, Matsuda K, Uehara S, Ohata S, Murata Y, Yamaji Y, Sakamoto K, Asami-Noyama M, Edakuni N, Hirano T, Kakugawa T, Murakami T, Takemura T, Matsunaga K. Ohteru Y, et al. Respir Med Case Rep. 2022 Feb 2;36:101600. doi: 10.1016/j.rmcr.2022.101600. eCollection 2022. Respir Med Case Rep. 2022. PMID: 35169540 Free PMC article. - CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients.
von Borstel A, Land J, Abdulahad WH, Rutgers A, Stegeman CA, Diepstra A, Heeringa P, Sanders JS. von Borstel A, et al. Front Immunol. 2019 Sep 24;10:2221. doi: 10.3389/fimmu.2019.02221. eCollection 2019. Front Immunol. 2019. PMID: 31608054 Free PMC article. - A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.
Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR. Ooi JD, et al. Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0. Nat Commun. 2019. PMID: 31358739 Free PMC article. - Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients.
Reijnders TDY, Stegeman CA, Huitema MG, Rutgers A, Heeringa P, Abdulahad WH. Reijnders TDY, et al. Sci Rep. 2019 Jun 4;9(1):8273. doi: 10.1038/s41598-019-44636-y. Sci Rep. 2019. PMID: 31164680 Free PMC article. - Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan's Syndrome.
Shamriz O, Tal Y, Gross M. Shamriz O, et al. J Immunol Res. 2018 Apr 23;2018:1498640. doi: 10.1155/2018/1498640. eCollection 2018. J Immunol Res. 2018. PMID: 29850616 Free PMC article. Review.
References
- Hum Pathol. 1981 May;12(5):458-67 - PubMed
- Gastroenterology. 1992 Mar;102(3):1090-1 - PubMed
- Pathol Res Pract. 1984 Mar;178(4):407-15 - PubMed
- N Engl J Med. 1988 Jun 23;318(25):1651-7 - PubMed
- Hum Pathol. 1988 Sep;19(9):1065-71 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical