Endocytosis of growth factor receptors - PubMed (original) (raw)
Review
Endocytosis of growth factor receptors
A Sorkin et al. Bioessays. 1993 Jun.
Abstract
Binding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor-mediated endocytosis, a process which involves clathrin-coated pits. After internalization into the endosomal compartment, a significant pool of GFs and GF receptors escape recycling to the cell surface and are sorted to the degradation pathway. The ligand-induced internalization and lysosomal degradation of GF receptors result in the dramatic loss of surface receptors, a phenomenon termed receptor down-regulation. In this review, we discuss relevant biochemical, morphological and kinetic studies of the mechanism of GF endocytosis, and the possible role of this process in mitogenic signaling by growth factor receptors.
Similar articles
- Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.
Marmor MD, Yarden Y. Marmor MD, et al. Oncogene. 2004 Mar 15;23(11):2057-70. doi: 10.1038/sj.onc.1207390. Oncogene. 2004. PMID: 15021893 Review. - Endocytic regulation of TGF-beta signaling.
Chen YG. Chen YG. Cell Res. 2009 Jan;19(1):58-70. doi: 10.1038/cr.2008.315. Cell Res. 2009. PMID: 19050695 Review. - Trafficking of asialoglycoproteins and the asialoglycoprotein receptor.
Schwartz AL. Schwartz AL. Targeted Diagn Ther. 1991;4:3-39. Targeted Diagn Ther. 1991. PMID: 1797161 Review. - Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking.
Madshus IH, Stang E. Madshus IH, et al. J Cell Sci. 2009 Oct 1;122(Pt 19):3433-9. doi: 10.1242/jcs.050260. J Cell Sci. 2009. PMID: 19759283
Cited by
- BDNF and activity-dependent synaptic modulation.
Lu B. Lu B. Learn Mem. 2003 Mar-Apr;10(2):86-98. doi: 10.1101/lm.54603. Learn Mem. 2003. PMID: 12663747 Free PMC article. Review. - HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.
Hendriks BS, Wiley HS, Lauffenburger D. Hendriks BS, et al. Biophys J. 2003 Oct;85(4):2732-45. doi: 10.1016/S0006-3495(03)74696-7. Biophys J. 2003. PMID: 14507736 Free PMC article. - Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies.
Longva KE, Blystad FD, Stang E, Larsen AM, Johannessen LE, Madshus IH. Longva KE, et al. J Cell Biol. 2002 Mar 4;156(5):843-54. doi: 10.1083/jcb.200106056. Epub 2002 Feb 25. J Cell Biol. 2002. PMID: 11864992 Free PMC article. - Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network.
Tzahar E, Moyer JD, Waterman H, Barbacci EG, Bao J, Levkowitz G, Shelly M, Strano S, Pinkas-Kramarski R, Pierce JH, Andrews GC, Yarden Y. Tzahar E, et al. EMBO J. 1998 Oct 15;17(20):5948-63. doi: 10.1093/emboj/17.20.5948. EMBO J. 1998. PMID: 9774339 Free PMC article. - Plasma Membrane Organization of Epidermal Growth Factor Receptor in Resting and Ligand-Bound States.
Bag N, Huang S, Wohland T. Bag N, et al. Biophys J. 2015 Nov 3;109(9):1925-36. doi: 10.1016/j.bpj.2015.09.007. Biophys J. 2015. PMID: 26536269 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources