Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse - PubMed (original) (raw)

Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse

H Nakano et al. Eur J Immunol. 1993 Oct.

Abstract

DDD/1 (DDD) mice were characterized by marked paucity of T cells in lymph nodes (LN). In DDD-Mtv-2/Mtv-2 (DDD-Mtv-2) congenics, T cells were 4- to 18-fold increased depending on ages but B cells doubled at the most. Thymus weight also increased. In DDDfDDD-Mtv-2, DDD neonatally infected with Mtv-2-derived exogenous MMTV (MMTV-2), neither LN cells nor thymus weight increased. The V beta 5+ and V beta 8+ T cell contents in LN were practically the same among three strains. The Mtv-2-induced expansion of LN T cells was polyclonal and appeared indigenous to DDD mice. Both Mtv-2 and MMTV-2 induced progressive age-dependent deletion of V beta 14+CD4+ LN cells. Mtv-2 but not MMTV-2 caused deletion of V beta 14+CD8+ LN cells and mature V beta 14+CD4+ thymocytes. Thus, Mtv-2- and MMTV-2-induced V beta 14+ T cell deletion may reflect intrathymic and peripheral elimination, respectively. The absence of I-E gene expression in DDD indicates that V beta 14+ T cell deletion advances independently of I-E molecules in this experimental system.

PubMed Disclaimer

Cited by

The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.
Vassileva G, Soto H, Zlotnik A, Nakano H, Kakiuchi T, Hedrick JA, Lira SA. Vassileva G, et al. J Exp Med. 1999 Oct 18;190(8):1183-8. doi: 10.1084/jem.190.8.1183. J Exp Med. 1999. PMID: 10523616 Free PMC article.

Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse - PubMed (original) (raw)