Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function - PubMed (original) (raw)
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function
S E Kahn et al. Diabetes. 1993 Nov.
Abstract
To determine the relationship between insulin sensitivity and beta-cell function, we quantified the insulin sensitivity index using the minimal model in 93 relatively young, apparently healthy human subjects of varying degrees of obesity (55 male, 38 female; 18-44 yr of age; body mass index 19.5-52.2 kg/m2) and with fasting glucose levels < 6.4 mM. SI was compared with measures of body adiposity and beta-cell function. Although lean individuals showed a wide range of SI, body mass index and SI were related in a curvilinear manner (P < 0.0001) so that on average, an increase in body mass index was associated generally with a lower value for SI. The relationship between the SI and the beta-cell measures was more clearly curvilinear and reciprocal for fasting insulin (P < 0.0001), first-phase insulin response (AIRglucose; P < 0.0001), glucose potentiation slope (n = 56; P < 0.005), and beta-cell secretory capacity (AIRmax; n = 43; P < 0.0001). The curvilinear relationship between SI and the beta-cell measures could not be distinguished from a hyperbola, i.e., SI x beta-cell function = constant. This hyperbolic relationship described the data significantly better than a linear function (P < 0.05). The nature of this relationship is consistent with a regulated feedback loop control system such that for any difference in SI, a proportionate reciprocal difference occurs in insulin levels and responses in subjects with similar carbohydrate tolerance. We conclude that in human subjects with normal glucose tolerance and varying degrees of obesity, beta-cell function varies quantitatively with differences in insulin sensitivity.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels.
Røder ME, Schwartz RS, Prigeon RL, Kahn SE. Røder ME, et al. J Clin Endocrinol Metab. 2000 Jun;85(6):2275-80. doi: 10.1210/jcem.85.6.6635. J Clin Endocrinol Metab. 2000. PMID: 10852463 - Diet-induced weight loss is associated with an improvement in beta-cell function in older men.
Utzschneider KM, Carr DB, Barsness SM, Kahn SE, Schwartz RS. Utzschneider KM, et al. J Clin Endocrinol Metab. 2004 Jun;89(6):2704-10. doi: 10.1210/jc.2003-031827. J Clin Endocrinol Metab. 2004. PMID: 15181045 Clinical Trial. - Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging.
Kahn SE, Larson VG, Schwartz RS, Beard JC, Cain KC, Fellingham GW, Stratton JR, Cerqueira MD, Abrass IB. Kahn SE, et al. J Clin Endocrinol Metab. 1992 Jun;74(6):1336-42. doi: 10.1210/jcem.74.6.1592879. J Clin Endocrinol Metab. 1992. PMID: 1592879 - Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function.
Chen M, Bergman RN, Pacini G, Porte D Jr. Chen M, et al. J Clin Endocrinol Metab. 1985 Jan;60(1):13-20. doi: 10.1210/jcem-60-1-13. J Clin Endocrinol Metab. 1985. PMID: 3880560 - Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity.
Kahn SE, Prigeon RL, Schwartz RS, Fujimoto WY, Knopp RH, Brunzell JD, Porte D Jr. Kahn SE, et al. J Nutr. 2001 Feb;131(2):354S-60S. doi: 10.1093/jn/131.2.354S. J Nutr. 2001. PMID: 11160560 Review.
Cited by
- Altered bile acids profile is a risk factor for hyperandrogenism in lean women with PCOS: a case control study.
Zhu Y, Lin S, Zhang Y, Yu J, Fu J, Li Y, Shan C, Cai J, Liu W, Tao T. Zhu Y, et al. Sci Rep. 2024 Oct 31;14(1):26215. doi: 10.1038/s41598-024-77645-7. Sci Rep. 2024. PMID: 39482365 Free PMC article. - Retinal microcirculation changes in prediabetic patients with short-term increased blood glucose using optical coherence tomography angiography.
Lv BJ, Zuo HJ, Li QF, Huang FF, Zhang T, Huang RX, Zheng SJ, Wan WJ, Hu K. Lv BJ, et al. World J Radiol. 2024 Sep 28;16(9):407-417. doi: 10.4329/wjr.v16.i9.407. World J Radiol. 2024. PMID: 39355394 Free PMC article. - Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.
Minato-Inokawa S, Tsuboi-Kaji A, Honda M, Takeuchi M, Kitaoka K, Kurata M, Wu B, Kazumi T, Fukuo K. Minato-Inokawa S, et al. Metabol Open. 2024 Jul 30;23:100306. doi: 10.1016/j.metop.2024.100306. eCollection 2024 Sep. Metabol Open. 2024. PMID: 39188637 Free PMC article. - Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women.
Minato-Inokawa S, Honda M, Tsuboi-Kaji A, Takeuchi M, Kitaoka K, Kurata M, Wu B, Kazumi T, Fukuo K. Minato-Inokawa S, et al. Sci Rep. 2024 Aug 10;14(1):18590. doi: 10.1038/s41598-024-69181-1. Sci Rep. 2024. PMID: 39127728 Free PMC article. - SHBG, Free Testosterone, and Type 2 Diabetes Risk in Middle-aged African Men: A Longitudinal Study.
Seipone ID, Mendham AE, Storbeck KH, Oestlund I, Kufe CN, Chikowore T, Masemola M, Crowther NJ, Kengne AP, Norris S, Olsson T, Brown T, Micklesfield LK, Goedecke JH. Seipone ID, et al. J Endocr Soc. 2024 Jul 19;8(8):bvae129. doi: 10.1210/jendso/bvae129. eCollection 2024 Jul 1. J Endocr Soc. 2024. PMID: 39055720 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources