Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B - PubMed (original) (raw)

. 1993 Sep 30;365(6445):412-9.

doi: 10.1038/365412a0.

Affiliations

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B

L D Kerr et al. Nature. 1993.

Abstract

The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappa B site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappa B enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources