Crystal structure of a yeast TBP/TATA-box complex - PubMed (original) (raw)
. 1993 Oct 7;365(6446):512-20.
doi: 10.1038/365512a0.
Affiliations
- PMID: 8413604
- DOI: 10.1038/365512a0
Crystal structure of a yeast TBP/TATA-box complex
Y Kim et al. Nature. 1993.
Abstract
The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.
Comment in
- Transcription. Opening the gateway.
Klug A. Klug A. Nature. 1993 Oct 7;365(6446):486-7. doi: 10.1038/365486a0. Nature. 1993. PMID: 8413598 No abstract available.
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