Identification of a Drosophila activin receptor - PubMed (original) (raw)

Comparative Study

Identification of a Drosophila activin receptor

S R Childs et al. Proc Natl Acad Sci U S A. 1993.

Abstract

Activins are cytokines of the transforming growth factor beta superfamily that control various events during vertebrate embryo development and cell differentiation in the adult, and act through transmembrane receptors that contain a cytoplasmic protein-serine/threonine kinase domain. We describe the identification, deduced primary structure, and expression pattern of Atr-II, a receptor serine/threonine kinase found in Drosophila. With the exception of the spacing of 10 cysteine residues, the extracellular domain of Atr-II is very dissimilar from those of vertebrate activin receptors, yet it binds activin with high affinity and specificity. The kinase domain sequence of Atr-II is 60% identical to those of activin receptors from vertebrates, suggesting similarities in their signaling mechanisms. Maternal Atr-II transcript and its product are abundant in the oocyte. During development, the highest levels of Atr-II transcript and protein are observed in the mesoderm and gut. The possible role of an activin signaling system in Drosophila development is discussed.

PubMed Disclaimer

Similar articles

• Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.
  Wrana JL, Tran H, Attisano L, Arora K, Childs SR, Massagué J, O'Connor MB. Wrana JL, et al. Mol Cell Biol. 1994 Feb;14(2):944-50. doi: 10.1128/mcb.14.2.944-950.1994. Mol Cell Biol. 1994. PMID: 8289834 Free PMC article.
• Molecular cloning of Xenopus activin type I receptor and the analysis of its expression during embryogenesis.
  Kondo M, Semba K, Shiokawa K, Yamamoto T. Kondo M, et al. Biochem Biophys Res Commun. 1996 Jan 17;218(2):549-55. doi: 10.1006/bbrc.1996.0098. Biochem Biophys Res Commun. 1996. PMID: 8561794
• Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.
  Tsuchida K, Mathews LS, Vale WW. Tsuchida K, et al. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11242-6. doi: 10.1073/pnas.90.23.11242. Proc Natl Acad Sci U S A. 1993. PMID: 8248234 Free PMC article.
• Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.
  Greenwald J, Fischer WH, Vale WW, Choe S. Greenwald J, et al. Nat Struct Biol. 1999 Jan;6(1):18-22. doi: 10.1038/4887. Nat Struct Biol. 1999. PMID: 9886286 Review.
• Serine/threonine kinase receptors.
  ten Dijke P, Franzén P, Yamashita H, Ichijo H, Heldin CH, Miyazono K. ten Dijke P, et al. Prog Growth Factor Res. 1994;5(1):55-72. doi: 10.1016/0955-2235(94)90017-5. Prog Growth Factor Res. 1994. PMID: 8199354 Review.

Cited by

• Bone morphogenetic protein signaling: the pathway and its regulation.
  Akiyama T, Raftery LA, Wharton KA. Akiyama T, et al. Genetics. 2024 Feb 7;226(2):iyad200. doi: 10.1093/genetics/iyad200. Genetics. 2024. PMID: 38124338 Free PMC article. Review.
• Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila.
  Bauer M, Aguilar G, Wharton KA, Matsuda S, Affolter M. Bauer M, et al. Dev Cell. 2023 Apr 24;58(8):645-659.e4. doi: 10.1016/j.devcel.2023.03.008. Epub 2023 Apr 12. Dev Cell. 2023. PMID: 37054707 Free PMC article.
• A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.
  Peterson AJ, Murphy SJ, Mundt MG, Shimell M, Leof EB, O'Connor MB. Peterson AJ, et al. PLoS Biol. 2022 May 20;20(5):e3001660. doi: 10.1371/journal.pbio.3001660. eCollection 2022 May. PLoS Biol. 2022. PMID: 35594316 Free PMC article.
• Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
  Upadhyay A, Peterson AJ, Kim MJ, O'Connor MB. Upadhyay A, et al. Elife. 2020 Jul 7;9:e51710. doi: 10.7554/eLife.51710. Elife. 2020. PMID: 32633716 Free PMC article.
• The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle.
  Langerak S, Kim MJ, Lamberg H, Godinez M, Main M, Winslow L, O'Connor MB, Zhu CC. Langerak S, et al. Biol Open. 2018 Apr 26;7(4):bio029454. doi: 10.1242/bio.029454. Biol Open. 2018. PMID: 29615416 Free PMC article.

References

1. 1. Nature. 1987 Jan 1-7;325(6099):81-4 - PubMed
2. 1. Cell. 1992 Dec 11;71(6):1003-14 - PubMed
3. 1. J Mol Biol. 1988 Sep 20;203(2):425-37 - PubMed
4. 1. Chromosoma. 1989 Aug;98(2):81-5 - PubMed
5. 1. Dev Biol. 1989 Dec;136(2):346-62 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • FlyBase
  • Gene Ontology

• Miscellaneous

  • NCI CPTAC Assay Portal
  • SciCrunch