Adherence of Helicobacter pylori to cultured human gastric epithelial cells - PubMed (original) (raw)

Adherence of Helicobacter pylori to cultured human gastric epithelial cells

D T Smoot et al. Infect Immun. 1993 Jan.

Abstract

Experiments were performed to demonstrate that adherence of Helicobacter pylori to gastric epithelial cells causes alterations in the cell cytoskeleton. H. pylori intimately attached to cultured human gastric epithelial cells on small cellular projections, while there was no intimate association of H. pylori with cultured human esophageal epithelial cells. Fluorescein-conjugated phalloidin staining of gastric epithelial cells showed that H. pylori adherence stimulated actin polymerization; this stimulation was not observed with esophageal cells. Also, this organism's selectivity for gastric mucosa was supported by rare binding of bacteria to esophageal epithelial cells and gastric fibroblasts.

PubMed Disclaimer

Similar articles

• Adherence of Helicobacter pylori to gastric epithelial cells and mucosal inflammation.
  Kaji T, Ishihara S, Ashizawa N, Hamamoto N, Endo H, Fukuda R, Adachi K, Watanabe M, Nakao M, Kinoshita Y. Kaji T, et al. J Lab Clin Med. 2002 Apr;139(4):244-50. doi: 10.1067/mlc.2002.122280. J Lab Clin Med. 2002. PMID: 12024112
• [The role of heat shock protein 60 (HSP60) of Helicobacter pylori in adhesion of H. pylori to human gastric epithelial cell].
  Yamaguchi H, Osaki T, Kurihara N, Taguchi H, Kamiya S. Yamaguchi H, et al. Kansenshogaku Zasshi. 1998 May;72(5):487-92. doi: 10.11150/kansenshogakuzasshi1970.72.487. Kansenshogaku Zasshi. 1998. PMID: 9642937 Japanese.
• Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection?
  Mueller A, Falkow S, Amieva MR. Mueller A, et al. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1859-64. doi: 10.1158/1055-9965.EPI-04-0820. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 16103426 Review.
• [Helicobacter pylori, gastric pathology, and histopathological diagnosis].
  Duchini A, Cassaro M, Genta RM. Duchini A, et al. Pathologica. 1997 Dec;89(6):583-91. Pathologica. 1997. PMID: 9549378 Italian. No abstract available.
• Carcinogenesis and infection with Helicobacter pylori.
  Micu G, Stăniceanu F, Zurac S, Bastian A, Gramadă E, Nichita L, Popp C, Sticlaru L, Andrei R, Socoliuc C. Micu G, et al. Rom J Intern Med. 2010;48(4):299-306. Rom J Intern Med. 2010. PMID: 21528757 Review.

Cited by

• Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87.
  Diesing AK, Nossol C, Faber-Zuschratter H, Zuschratter W, Renner L, Sokolova O, Naumann M, Rothkötter HJ. Diesing AK, et al. Anat Rec (Hoboken). 2013 Dec;296(12):1800-5. doi: 10.1002/ar.22818. Epub 2013 Oct 17. Anat Rec (Hoboken). 2013. PMID: 24136815 Free PMC article.
• Electron microscopic evaluation of adhesion of Helicobacter pylori to the gastric epithelial cells in chronic gastritis.
  Chun HJ, Park DK, Park CH, Park JH, Jeen YT, Um SH, Lee SW, Choi JH, Kim CD, Ryu HS, Hyun JH, Chae YS, Uhm CS. Chun HJ, et al. Korean J Intern Med. 2002 Mar;17(1):45-50. doi: 10.3904/kjim.2002.17.1.45. Korean J Intern Med. 2002. PMID: 12014212 Free PMC article.
• Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.
  Kabir AM, Aiba Y, Takagi A, Kamiya S, Miwa T, Koga Y. Kabir AM, et al. Gut. 1997 Jul;41(1):49-55. doi: 10.1136/gut.41.1.49. Gut. 1997. PMID: 9274471 Free PMC article.
• Cytokine expression and production by purified Helicobacter pylori urease in human gastric epithelial cells.
  Tanahashi T, Kita M, Kodama T, Yamaoka Y, Sawai N, Ohno T, Mitsufuji S, Wei YP, Kashima K, Imanishi J. Tanahashi T, et al. Infect Immun. 2000 Feb;68(2):664-71. doi: 10.1128/IAI.68.2.664-671.2000. Infect Immun. 2000. PMID: 10639431 Free PMC article.
• Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).
  Shirin H, Sordillo EM, Kolevska TK, Hibshoosh H, Kawabata Y, Oh SH, Kuebler JF, Delohery T, Weghorst CM, Weinstein IB, Moss SF. Shirin H, et al. Infect Immun. 2000 Sep;68(9):5321-8. doi: 10.1128/IAI.68.9.5321-5328.2000. Infect Immun. 2000. PMID: 10948161 Free PMC article.

References

1. 1. Cancer Res. 1983 Apr;43(4):1703-9 - PubMed
2. 1. In Vitro Cell Dev Biol. 1985 Mar;21(3 Pt 1):154-60 - PubMed
3. 1. J Infect Dis. 1985 Sep;152(3):560-5 - PubMed
4. 1. J Clin Pathol. 1986 Apr;39(4):353-65 - PubMed
5. 1. Am J Clin Pathol. 1986 Nov;86(5):575-82 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Medical

  • MedlinePlus Health Information