A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus - PubMed (original) (raw)

A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus

S P Wang et al. Proc Natl Acad Sci U S A. 1993.

Abstract

Mutations having pleiotropic effects on polar organelle development (pod) in Caulobacter crescentus have been identified and shown to occur in at least 13 genes scattered throughout the genome. Mutations at each locus affect a unique combination of polar traits, suggesting that complex interactions occur among these genes. The DNA sequence of one of these genes, pleC, indicates that it is homologous to members of the family of histidine protein kinase genes. Membes of this family include the senor components of the bacterial two-component regulatory systems. Furthermore, in vitro experiments demonstrated that the PleC protein was capable of autophosphorylation. These results suggest that the PleC protein (and perhaps the proteins encoded by the other pod genes as well) regulates the expression of genes involved in polar organelle development through the phosphorylation of key regulatory proteins. The use of a phosphorelay system cued to internal changes in the cell would provide a mechanism for coordinating major changes in gene expression with the completion of specific cell cycle events.

PubMed Disclaimer

Similar articles

• The Caulobacter crescentus polar organelle development protein PodJ is differentially localized and is required for polar targeting of the PleC development regulator.
  Hinz AJ, Larson DE, Smith CS, Brun YV. Hinz AJ, et al. Mol Microbiol. 2003 Feb;47(4):929-41. doi: 10.1046/j.1365-2958.2003.03349.x. Mol Microbiol. 2003. PMID: 12581350
• A dynamically localized histidine kinase controls the asymmetric distribution of polar pili proteins.
  Viollier PH, Sternheim N, Shapiro L. Viollier PH, et al. EMBO J. 2002 Sep 2;21(17):4420-8. doi: 10.1093/emboj/cdf454. EMBO J. 2002. PMID: 12198144 Free PMC article.
• Roles of the histidine protein kinase pleC in Caulobacter crescentus motility and chemotaxis.
  Burton GJ, Hecht GB, Newton A. Burton GJ, et al. J Bacteriol. 1997 Sep;179(18):5849-53. doi: 10.1128/jb.179.18.5849-5853.1997. J Bacteriol. 1997. PMID: 9294444 Free PMC article.
• Spatial and temporal control of differentiation and cell cycle progression in Caulobacter crescentus.
  Ausmees N, Jacobs-Wagner C. Ausmees N, et al. Annu Rev Microbiol. 2003;57:225-47. doi: 10.1146/annurev.micro.57.030502.091006. Annu Rev Microbiol. 2003. PMID: 14527278 Review.
• Two-component signaling systems and cell cycle control in Caulobacter crescentus.
  Purcell EB, Boutte CC, Crosson S. Purcell EB, et al. Adv Exp Med Biol. 2008;631:122-30. doi: 10.1007/978-0-387-78885-2_8. Adv Exp Med Biol. 2008. PMID: 18792685 Review.

Cited by

• Complete genome sequence of Caulobacter crescentus bacteriophage φCbK.
  Panis G, Lambert C, Viollier PH. Panis G, et al. J Virol. 2012 Sep;86(18):10234-5. doi: 10.1128/JVI.01579-12. J Virol. 2012. PMID: 22923796 Free PMC article.
• The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus.
  Hallez R, Mignolet J, Van Mullem V, Wery M, Vandenhaute J, Letesson JJ, Jacobs-Wagner C, De Bolle X. Hallez R, et al. EMBO J. 2007 Mar 7;26(5):1444-55. doi: 10.1038/sj.emboj.7601577. Epub 2007 Feb 15. EMBO J. 2007. PMID: 17304218 Free PMC article.
• An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter.
  Wu J, Ohta N, Newton A. Wu J, et al. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1443-8. doi: 10.1073/pnas.95.4.1443. Proc Natl Acad Sci U S A. 1998. PMID: 9465034 Free PMC article.
• A comparison of the Caulobacter NA1000 and K31 genomes reveals extensive genome rearrangements and differences in metabolic potential.
  Ash K, Brown T, Watford T, Scott LE, Stephens C, Ely B. Ash K, et al. Open Biol. 2014 Oct;4(10):140128. doi: 10.1098/rsob.140128. Open Biol. 2014. PMID: 25274120 Free PMC article.
• The control of asymmetric gene expression during Caulobacter cell differentiation.
  Marczynski GT, Shapiro L. Marczynski GT, et al. Arch Microbiol. 1995 May;163(5):313-21. doi: 10.1007/BF00404203. Arch Microbiol. 1995. PMID: 7794099 Review.

References

1. 1. J Bacteriol. 1989 Jun;171(6):3218-27 - PubMed
2. 1. J Bacteriol. 1989 Mar;171(3):1554-61 - PubMed
3. 1. J Clin Microbiol. 1989 Nov;27(11):2612-5 - PubMed
4. 1. Genetics. 1989 Dec;123(4):649-54 - PubMed
5. 1. J Bacteriol. 1990 Feb;172(2):525-30 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Miscellaneous

  • NCI CPTAC Assay Portal