Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue sarcomas of the adult--an EORTC Soft Tissue and Bone Sarcoma Group Study - PubMed (original) (raw)
Clinical Trial
Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue sarcomas of the adult--an EORTC Soft Tissue and Bone Sarcoma Group Study
J Verweij et al. Eur J Cancer. 1993.
Abstract
The EORTC Soft Tissue and Bone Sarcoma Group conducted a phase II study with oral miltefosine at a dose of 50 mg thrice daily in patients with metastatic soft tissue sarcomas. No responses were seen in 18 evaluable patients. Toxicity consisted mainly of nausea/vomiting. It is concluded that oral miltefosine has no activity in soft tissue sarcoma.
Similar articles
- Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer.
Planting AS, Stoter G, Verweij J. Planting AS, et al. Eur J Cancer. 1993;29A(4):518-9. doi: 10.1016/s0959-8049(05)80142-x. Eur J Cancer. 1993. PMID: 8435202 Clinical Trial. - Phase II study of liposomal muramyl tripeptide phosphatidylethanolamine (MTP/PE) in advanced soft tissue sarcomas of the adult. An EORTC Soft Tissue and Bone Sarcoma Group study.
Verweij J, Judson I, Steward W, Coleman R, Woll P, van Pottelsberghe C, van Glabbeke M, Mouridsen H. Verweij J, et al. Eur J Cancer. 1994;30A(6):842-3. doi: 10.1016/0959-8049(94)90303-4. Eur J Cancer. 1994. PMID: 7917546 Clinical Trial. - Phase II evaluation of amonafide in advanced sarcoma: a Southwest Oncology Group study.
Buys SS, Metch B, Balcerzak SP, Neefe JR, Stuckey WJ. Buys SS, et al. Cancer Invest. 1994;12(4):399-402. doi: 10.3109/07357909409038230. Cancer Invest. 1994. PMID: 8032960 Clinical Trial. - Chemotherapy of advanced sarcomas of bone and soft tissue.
Antman KH. Antman KH. Semin Oncol. 1992 Dec;19(6 Suppl 12):13-20. Semin Oncol. 1992. PMID: 1485169 Review. - [Chemotherapy of soft tissue sarcoma in adults].
Rouëssé J, Spielmann M, Le Chevalier T, Tubiana-Hulin M, Tursz T. Rouëssé J, et al. Bull Acad Natl Med. 1991 Nov;175(8):1251-9; discussion 1259-60. Bull Acad Natl Med. 1991. PMID: 1809496 Review. French.
Cited by
- The safety and efficacy of miltefosine in the long-term treatment of post-kala-azar dermal leishmaniasis in South Asia - A review and meta-analysis.
Pijpers J, den Boer ML, Essink DR, Ritmeijer K. Pijpers J, et al. PLoS Negl Trop Dis. 2019 Feb 11;13(2):e0007173. doi: 10.1371/journal.pntd.0007173. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30742620 Free PMC article. Review. - Tumor-selective anti-cancer effects of the synthetic alkyl phosphocholine analog CLR1404 in neuroblastoma.
Marino R, Baiu DC, Bhattacharya S, Titz B, Hebron E, Menapace BD, Singhal S, Eickhoff JC, Asimakopoulos F, Weichert JP, Otto M. Marino R, et al. Am J Cancer Res. 2015 Oct 15;5(11):3422-35. eCollection 2015. Am J Cancer Res. 2015. PMID: 26807322 Free PMC article. - Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review).
Nitulescu GM, Margina D, Juzenas P, Peng Q, Olaru OT, Saloustros E, Fenga C, Spandidos DΑ, Libra M, Tsatsakis AM. Nitulescu GM, et al. Int J Oncol. 2016 Mar;48(3):869-85. doi: 10.3892/ijo.2015.3306. Epub 2015 Dec 24. Int J Oncol. 2016. PMID: 26698230 Free PMC article. Review. - A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms.
Figg WD, Monga M, Headlee D, Shah A, Chau CH, Peer C, Messman R, Elsayed YA, Murgo AJ, Melillo G, Ryan QC, Kalnitskiy M, Senderowicz AM, Hollingshead M, Arbuck SG, Sausville EA. Figg WD, et al. Cancer Chemother Pharmacol. 2014 Nov;74(5):955-67. doi: 10.1007/s00280-014-2569-7. Epub 2014 Sep 3. Cancer Chemother Pharmacol. 2014. PMID: 25183650 Free PMC article. Clinical Trial. - Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer.
Terwogt JM, Mandjes IA, Sindermann H, Beijnen JH, ten Bokkel Huinink WW. Terwogt JM, et al. Br J Cancer. 1999 Mar;79(7-8):1158-61. doi: 10.1038/sj.bjc.6690184. Br J Cancer. 1999. PMID: 10098751 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical