Reactive glia as rivals in regulating neuronal survival - PubMed (original) (raw)
Reactive glia as rivals in regulating neuronal survival
D Giulian. Glia. 1993 Jan.
Abstract
Reactive gliosis is a response noted after nearly every type of CNS injury and involves both activated microglia and astroglia. Although many investigators believe that reactive glia in some way regulate the survival of injured neurons, the influence of glial elements upon damaged neural tissues remains uncertain. To examine relationships between reactive glia and neurons, secretion products from both microglia and astroglia are tested for their effects upon the survival of cultured neurons. Microglia are found to secrete neurotoxic agents, while astroglia are a source of neuronotrophic factors. Similar patterns of soluble factor production are noted for astroglia-rich or microglia-rich regions of rat neocortex damaged by ischemia. These observations suggest that microglia and astroglia compete for control of neuronal survival. Importantly, microglial neurotoxins might hinder the recovery of neurologic function at sites of inflammation.
Similar articles
- Brain glia release factors with opposing actions upon neuronal survival.
Giulian D, Vaca K, Corpuz M. Giulian D, et al. J Neurosci. 1993 Jan;13(1):29-37. doi: 10.1523/JNEUROSCI.13-01-00029.1993. J Neurosci. 1993. PMID: 8423475 Free PMC article. - Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture.
Gallo F, Morale MC, Spina-Purrello V, Tirolo C, Testa N, Farinella Z, Avola R, Beaudet A, Marchetti B. Gallo F, et al. Synapse. 2000 Jun 15;36(4):233-53. doi: 10.1002/(SICI)1098-2396(20000615)36:4<233::AID-SYN1>3.0.CO;2-I. Synapse. 2000. PMID: 10819902 - Neuronal survival and glial reactions after recurrent laryngeal nerve resection in the rat.
Hydman J, Svensson M, Kuylenstierna R, Ohlsson M, Mattsson P. Hydman J, et al. Laryngoscope. 2005 Apr;115(4):619-24. doi: 10.1097/01.mlg.0000161362.43320.b2. Laryngoscope. 2005. PMID: 15805870 - Endocrine glia: roles of glial cells in the brain actions of steroid and thyroid hormones and in the regulation of hormone secretion.
Garcia-Segura LM, Chowen JA, Naftolin F. Garcia-Segura LM, et al. Front Neuroendocrinol. 1996 Apr;17(2):180-211. doi: 10.1006/frne.1996.0005. Front Neuroendocrinol. 1996. PMID: 8812295 Review. - Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.
Garcia-Ovejero D, Azcoitia I, Doncarlos LL, Melcangi RC, Garcia-Segura LM. Garcia-Ovejero D, et al. Brain Res Brain Res Rev. 2005 Apr;48(2):273-86. doi: 10.1016/j.brainresrev.2004.12.018. Epub 2005 Jan 15. Brain Res Brain Res Rev. 2005. PMID: 15850667 Review.
Cited by
- Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils.
Yoo KY, Kim IH, Cho JH, Ahn JH, Park JH, Lee JC, Tae HJ, Kim DW, Kim JD, Hong S, Won MH, Kang IJ. Yoo KY, et al. Neural Regen Res. 2016 Feb;11(2):270-7. doi: 10.4103/1673-5374.177735. Neural Regen Res. 2016. PMID: 27073380 Free PMC article. - In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging.
Kawai Y, Aoki I, Umeda M, Higuchi T, Kershaw J, Higuchi M, Silva AC, Tanaka C. Kawai Y, et al. Neuroimage. 2010 Feb 15;49(4):3122-31. doi: 10.1016/j.neuroimage.2009.11.005. Epub 2009 Nov 10. Neuroimage. 2010. PMID: 19909819 Free PMC article. - Neuronal death: is there a role for astrocytes?
Tacconi MT. Tacconi MT. Neurochem Res. 1998 May;23(5):759-65. doi: 10.1023/a:1022463527474. Neurochem Res. 1998. PMID: 9566616 Review. - Aortic coarctation hypertension induces fibroblast growth factor-2 immunoreactivity in the stimulated nucleus tractus solitarii.
Fior-Chadi DR, Varella TC, Maximino JR, Chadi G. Fior-Chadi DR, et al. J Mol Histol. 2007 Aug;38(4):285-94. doi: 10.1007/s10735-007-9101-x. Epub 2007 Jun 12. J Mol Histol. 2007. PMID: 17562191 - The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.
Giulian D, Wendt E, Vaca K, Noonan CA. Giulian D, et al. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2769-73. doi: 10.1073/pnas.90.7.2769. Proc Natl Acad Sci U S A. 1993. PMID: 8464887 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources