A wingless-dependent polar coordinate system in Drosophila imaginal discs - PubMed (original) (raw)
Comparative Study
. 1993 Jan 22;259(5094):484-9.
doi: 10.1126/science.8424170.
Affiliations
- PMID: 8424170
- DOI: 10.1126/science.8424170
Comparative Study
A wingless-dependent polar coordinate system in Drosophila imaginal discs
J P Couso et al. Science. 1993.
Abstract
The patterning of the imaginal discs in Drosophila melanogaster is a progressive process that, like the patterning of the larval epidermis during embryogenesis, requires the activity of segment polarity genes. One segment polarity gene, wingless, encodes a homolog of the mouse proto-oncogene Wnt-1 and plays a prominent role in the patterning of the larval epidermis and the imaginal discs. However, whereas the function of wingless in the embryo is initially associated with a pattern of stripes along the anteroposterior axis that are part of a Cartesian coordinate system, it is shown here that during imaginal development wingless is associated with a pattern of sectors that provide references for a polar coordinate system homologous to that postulated in a well-known model for the regeneration of insect and vertebrate limbs.
Comment in
- The polar coordinate model goes molecular.
Bryant PJ. Bryant PJ. Science. 1993 Jan 22;259(5094):471-2. doi: 10.1126/science.8424169. Science. 1993. PMID: 8424169 No abstract available.
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