Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites - PubMed (original) (raw)
Comparative Study
. 1993 Jan 29;72(2):223-32.
doi: 10.1016/0092-8674(93)90662-a.
Affiliations
- PMID: 8425219
- DOI: 10.1016/0092-8674(93)90662-a
Comparative Study
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites
A S Zervos et al. Cell. 1993.
Erratum in
- Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites.
Zervos AS, Gyuris J, Brent R. Zervos AS, et al. Cell. 1994 Oct 21;79(2):following 388. Cell. 1994. PMID: 7954804 No abstract available.
Abstract
We used the interaction trap to isolate a novel human protein that specifically interacts with Max. This protein, Mxi1 (for Max interactor 1), contains a bHLH-Zip motif that is similar to that found in Myc family proteins. Mxi1 interacts specifically with Max to form heterodimers that efficiently bind to the Myc-Max consensus recognition site. When bound to DNA by a LexA moiety in yeast, Mxi1 does not stimulate transcription. mxi1 mRNA is expressed in many tissues, and its expression is elevated in U-937 myeloid leukemia cells that have been stimulated to differentiate. These facts are consistent with a model in which Mxi1-Max heterodimers indirectly inhibit Myc function in two ways: first, by sequestering Max, thus preventing the formation of Myc-Max heterodimers, and second, by competing with Myc-Max heterodimers for binding to target sites.
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