The glomerular mesangium in diabetes mellitus - PubMed (original) (raw)
The glomerular mesangium in diabetes mellitus
J I Kreisberg et al. Kidney Int. 1993 Jan.
Free article
Abstract
Like the renal glomerular mesangium in patients with diabetic nephropathy, glomerular mesangial cell cultures grown in 30 mM glucose accumulate increased amounts of the extracellular matrix (ECM) proteins fibronectin, laminin, and type IV collagen. This is due to increased ECM protein synthesis and mRNA levels. Similar to other cells types that are affected by the diabetic state (such as, vascular cells and peripheral nerve), mesangial cells transport glucose by an insulin-independent, facilitated diffusion transport system. Kinetic studies reveal that intracellular glucose levels may reach the ambient glucose concentrations achieved in diabetes. Growth studies reveal that glucose does not exert its effect on mesangial cell ECM accumulation by affecting cell growth, but rather it causes an increase in diacylglycerol (DAG) mass and activates protein kinase C. Agents such as phorbol myristate acetate (PMA) and the cell permeable DAG analogue, oleoyl acetyl glycerol (OAG) which activate protein kinase C also increase ECM mRNAs. These results implicate protein kinase C activation in the increased ECM accumulation observed in mesangial cell cultures grown in high glucose.
Similar articles
- High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures.
Ayo SH, Radnik R, Garoni JA, Troyer DA, Kreisberg JI. Ayo SH, et al. Am J Physiol. 1991 Oct;261(4 Pt 2):F571-7. doi: 10.1152/ajprenal.1991.261.4.F571. Am J Physiol. 1991. PMID: 1928372 - High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells.
Ayo SH, Radnik RA, Garoni JA, Glass WF 2nd, Kreisberg JI. Ayo SH, et al. Am J Pathol. 1990 Jun;136(6):1339-48. Am J Pathol. 1990. PMID: 2356864 Free PMC article. - Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen alpha 1 (IV) in glomerular mesangial cells.
Ziyadeh FN, Fumo P, Rodenberger CH, Kuncio GS, Neilson EG. Ziyadeh FN, et al. J Diabetes Complications. 1995 Oct-Dec;9(4):255-61. doi: 10.1016/1056-8727(95)80016-8. J Diabetes Complications. 1995. PMID: 8573741 Review. - Mesangial cell dysfunction as a pathogenesis of diabetic nephropathy.
Haneda M, Koya D, Kikkawa R. Haneda M, et al. Contrib Nephrol. 2001;(134):16-29. doi: 10.1159/000060149. Contrib Nephrol. 2001. PMID: 11665284 Review. No abstract available.
Cited by
- Pathomechanisms of Diabetic Kidney Disease.
Sinha SK, Nicholas SB. Sinha SK, et al. J Clin Med. 2023 Nov 27;12(23):7349. doi: 10.3390/jcm12237349. J Clin Med. 2023. PMID: 38068400 Free PMC article. Review. - The role of protein kinase C in diabetic microvascular complications.
Pan D, Xu L, Guo M. Pan D, et al. Front Endocrinol (Lausanne). 2022 Aug 17;13:973058. doi: 10.3389/fendo.2022.973058. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36060954 Free PMC article. Review. - p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin.
Molnar Z, Millward AB, Tse W, Demaine AG. Molnar Z, et al. Int J Chronic Dis. 2014;2014:327640. doi: 10.1155/2014/327640. Epub 2014 Mar 25. Int J Chronic Dis. 2014. PMID: 26464852 Free PMC article. - Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy.
Fadini GP, Mancuso P, Bertolini F, de Kreutzenberg S, Avogaro A. Fadini GP, et al. Exp Diabetes Res. 2012;2012:274363. doi: 10.1155/2012/274363. Epub 2012 Feb 28. Exp Diabetes Res. 2012. PMID: 22474419 Free PMC article. Clinical Trial. - Effects of Panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus.
Tu QN, Dong H, Lu FE. Tu QN, et al. Chin J Integr Med. 2011 Aug;17(8):612-5. doi: 10.1007/s11655-011-0825-9. Epub 2011 Aug 9. Chin J Integr Med. 2011. PMID: 21826596
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical