Myogenic regulatory factors: dissecting their role and regulation during vertebrate embryogenesis - PubMed (original) (raw)
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Myogenic regulatory factors: dissecting their role and regulation during vertebrate embryogenesis
D A Sassoon. Dev Biol. 1993 Mar.
Free article
Abstract
The elucidation of the myogenic regulatory factors (MRFs) has resulted in a surge of research activity that promises to bridge molecular and embryological approaches to muscle research. In this review, we consider the arguments that would place MRFs in a key determination role for the skeletal muscle lineage in the vertebrate embryo. Amphibian, avian, and murine systems are compared and recent developments in the molecular embryology of myogenesis are reviewed. A model is proposed to account for the apparent discrepancies in conclusions drawn from studies using cultured cells that indicate a role for the MRFs in determination, and studies of MRF and muscle gene expression in vivo that indicate a role in differentiation but not in lineage determination.
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