Multiple defects of immune cell function in mice with disrupted interferon-gamma genes - PubMed (original) (raw)

. 1993 Mar 19;259(5102):1739-42.

doi: 10.1126/science.8456300.

Affiliations

• PMID: 8456300
• DOI: 10.1126/science.8456300

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

D K Dalton et al. Science. 1993.

Abstract

Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system.

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Comment in

• Immunology. Interfering with interferon.
  Barinaga M. Barinaga M. Science. 1993 Mar 19;259(5102):1693-4. doi: 10.1126/science.8456294. Science. 1993. PMID: 8456294 No abstract available.

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