Thymus epithelium induces tissue-specific tolerance - PubMed (original) (raw)
Thymus epithelium induces tissue-specific tolerance
A Bonomo et al. J Exp Med. 1993.
Abstract
Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.
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References
- Science. 1990 Mar 23;247(4949 Pt 1):1471-4 - PubMed
- Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10420-4 - PubMed
- Science. 1990 Jun 29;248(4963):1643-6 - PubMed
- Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:183-9 - PubMed
- Cold Spring Harb Symp Quant Biol. 1989;54 Pt 2:799-805 - PubMed
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