Significance of duplicated flagellin genes in Campylobacter - PubMed (original) (raw)
Comparative Study
. 1993 Mar 20;230(2):359-63.
doi: 10.1006/jmbi.1993.1151.
Affiliations
- PMID: 8464049
- DOI: 10.1006/jmbi.1993.1151
Comparative Study
Significance of duplicated flagellin genes in Campylobacter
R A Alm et al. J Mol Biol. 1993.
Abstract
The complex flagellum of Campylobacter coli VC167 contains two highly related (98%) flagellin subunit proteins which are produced from two 92% homologous, tandemly orientated genes, flaA and flaB. Mutants expressing only flaA form a full-length flagellar filament that confers slightly less than wild-type motility to the bacterium. However, flagellin mutants expressing only flaB produce extremely short, truncated filaments, and are only slightly motile. We have shown that the presence of two essentially identical genes is advantageous, in that flaAflaB+ mutants become highly motile upon passage by an event which allows the production of a full length simple flagellar filament containing a single FlaA-FlaB chimeric flagellin protein. Furthermore, we have demonstrated that the reassortment of DNA that results in this chimeric protein can occur by two mechanisms: intragenomic recombination and transformation-mediated intergenomic recombination.
Similar articles
- Distribution and polymorphism of the flagellin genes from isolates of Campylobacter coli and Campylobacter jejuni.
Alm RA, Guerry P, Trust TJ. Alm RA, et al. J Bacteriol. 1993 May;175(10):3051-7. doi: 10.1128/jb.175.10.3051-3057.1993. J Bacteriol. 1993. PMID: 8098328 Free PMC article. - The Campylobacter sigma 54 flaB flagellin promoter is subject to environmental regulation.
Alm RA, Guerry P, Trust TJ. Alm RA, et al. J Bacteriol. 1993 Jul;175(14):4448-55. doi: 10.1128/jb.175.14.4448-4455.1993. J Bacteriol. 1993. PMID: 8331072 Free PMC article. - Role of two flagellin genes in Campylobacter motility.
Guerry P, Alm RA, Power ME, Logan SM, Trust TJ. Guerry P, et al. J Bacteriol. 1991 Aug;173(15):4757-64. doi: 10.1128/jb.173.15.4757-4764.1991. J Bacteriol. 1991. PMID: 1856171 Free PMC article. - Structural and antigenic characteristics of Campylobacter coli FlaA flagellin.
Power ME, Guerry P, McCubbin WD, Kay CM, Trust TJ. Power ME, et al. J Bacteriol. 1994 Jun;176(11):3303-13. doi: 10.1128/jb.176.11.3303-3313.1994. J Bacteriol. 1994. PMID: 7515043 Free PMC article. - The bacterial flagellin gene as a biomarker for detection, population genetics and epidemiological analysis.
Winstanley C, Morgan JAW. Winstanley C, et al. Microbiology (Reading). 1997 Oct;143 ( Pt 10):3071-3084. doi: 10.1099/00221287-143-10-3071. Microbiology (Reading). 1997. PMID: 9353913 Review. No abstract available.
Cited by
- The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence.
Gabbert AD, Mydosh JL, Talukdar PK, Gloss LM, McDermott JE, Cooper KK, Clair GC, Konkel ME. Gabbert AD, et al. Biomolecules. 2023 Jan 9;13(1):135. doi: 10.3390/biom13010135. Biomolecules. 2023. PMID: 36671522 Free PMC article. Review. - The Distribution of Campylobacter jejuni Virulence Genes in Genomes Worldwide Derived from the NCBI Pathogen Detection Database.
Panzenhagen P, Portes AB, Dos Santos AMP, Duque SDS, Conte Junior CA. Panzenhagen P, et al. Genes (Basel). 2021 Sep 28;12(10):1538. doi: 10.3390/genes12101538. Genes (Basel). 2021. PMID: 34680933 Free PMC article. - Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.
Nedeljković M, Sastre DE, Sundberg EJ. Nedeljković M, et al. Int J Mol Sci. 2021 Jul 14;22(14):7521. doi: 10.3390/ijms22147521. Int J Mol Sci. 2021. PMID: 34299141 Free PMC article. Review. - Importance of Campylobacter jejuni FliS and FliW in Flagella Biogenesis and Flagellin Secretion.
Radomska KA, Wösten MMSM, Ordoñez SR, Wagenaar JA, van Putten JPM. Radomska KA, et al. Front Microbiol. 2017 Jun 12;8:1060. doi: 10.3389/fmicb.2017.01060. eCollection 2017. Front Microbiol. 2017. PMID: 28659885 Free PMC article. - The Minor Flagellin of Campylobacter jejuni (FlaB) Confers Defensive Properties against Bacteriophage Infection.
Lis L, Connerton IF. Lis L, et al. Front Microbiol. 2016 Nov 29;7:1908. doi: 10.3389/fmicb.2016.01908. eCollection 2016. Front Microbiol. 2016. PMID: 27965643 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources