Hypolipidemic effects of beta-cyclodextrin in the hamster and in the genetically hypercholesterolemic Rico rat - PubMed (original) (raw)

Comparative Study

doi: 10.1007/BF02536637.

Affiliations

• PMID: 8464348
• DOI: 10.1007/BF02536637

Comparative Study

Hypolipidemic effects of beta-cyclodextrin in the hamster and in the genetically hypercholesterolemic Rico rat

M Riottot et al. Lipids. 1993 Mar.

Abstract

The effect of increasing amounts of a cyclic oligosaccharide, beta-cyclodextrin (BCD), included in the diet on plasma cholesterol and triglycerides, was investigated in two animal models, namely in male genetically hypercholesterolemic Rico rats and in male Syrian hamsters. The distribution of bile acids in the gastrointestinal tract and in the feces of hamsters was also determined. In the Rico rats and hamsters, plasma cholesterol and triglycerides decreased linearly with increasing doses of BCD. In these two species, 20% BCD as compared to control diet lowered cholesterolemia (-35%) and triglyceridemia (-70%). In the hamster, the BCD diet caused a marked decrease in cholesterol and triglycerides in chylomicrons and very low density lipoprotein, and in high density lipoproteins cholesterol. Composition and amounts of bile acids were modified in the gastrointestinal tract of hamsters receiving 10% BCD as compared to the control group. The total bile acid content of the gallbladder of treated hamsters was fourfold higher than in the control group, and the bile contained a large amount of hydrophilic bile acids. This trend was also observed in the small intestine, in which percentages and total quantities of cholic plus deoxycholic acids (cholic pathway) were higher than those of chenodeoxycholic plus ursodeoxycholic plus lithocholic acids (chenodeoxycholic pathway). The bile acid contents of the cecum and colon of treated hamsters were 2.7-fold higher than those of control animals, but the bile acid composition was similar in the two groups of hamsters.(ABSTRACT TRUNCATED AT 250 WORDS)

PubMed Disclaimer

Similar articles

• Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine.
  Boehler N, Riottot M, Férézou J, Souidi M, Milliat F, Sérougne C, Smith JL, Lutton C. Boehler N, et al. J Lipid Res. 1999 Apr;40(4):726-34. J Lipid Res. 1999. PMID: 10191297
• Impact of beta-cyclodextrin and resistant starch on bile acid metabolism and fecal steroid excretion in regard to their hypolipidemic action in hamsters.
  Trautwein EA, Forgbert K, Rieckhoff D, Erbersdobler HF. Trautwein EA, et al. Biochim Biophys Acta. 1999 Jan 29;1437(1):1-12. doi: 10.1016/s0005-2760(98)00174-x. Biochim Biophys Acta. 1999. PMID: 9931405
• Studies of cholesterol and bile acid metabolism, and early atherogenesis in hamsters fed GT16-239, a novel bile acid sequestrant (BAS).
  Wilson TA, Nicolosi RJ, Rogers EJ, Sacchiero R, Goldberg DJ. Wilson TA, et al. Atherosclerosis. 1998 Oct;140(2):315-24. doi: 10.1016/s0021-9150(98)00135-x. Atherosclerosis. 1998. PMID: 9862274
• Steroid pattern of bile and feces in response to a fruit-enriched diet in hypercholesterolemic hamsters.
  Sablé R, Sicart R, Berry E. Sablé R, et al. Ann Nutr Metab. 1990;34(5):303-10. doi: 10.1159/000177602. Ann Nutr Metab. 1990. PMID: 2244751
• The hypocholesterolemic and antiatherogenic effects of Cholazol H, a chemically functionalized insoluble fiber with bile acid sequestrant properties in hamsters.
  Wilson TA, Romano C, Liang J, Nicolosi RJ. Wilson TA, et al. Metabolism. 1998 Aug;47(8):959-64. doi: 10.1016/s0026-0495(98)90351-1. Metabolism. 1998. PMID: 9711992

Cited by

• Cholesterol in the Cell Membrane-An Emerging Player in Atherogenesis.
  Paukner K, Králová Lesná I, Poledne R. Paukner K, et al. Int J Mol Sci. 2022 Jan 4;23(1):533. doi: 10.3390/ijms23010533. Int J Mol Sci. 2022. PMID: 35008955 Free PMC article. Review.
• Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces.
  Abadie C, Hug M, Kübli C, Gains N. Abadie C, et al. Biochem J. 1994 May 1;299 ( Pt 3)(Pt 3):725-30. doi: 10.1042/bj2990725. Biochem J. 1994. PMID: 8192660 Free PMC article.
• Rethinking reverse cholesterol transport and dysfunctional high-density lipoproteins.
  Gillard BK, Rosales C, Xu B, Gotto AM Jr, Pownall HJ. Gillard BK, et al. J Clin Lipidol. 2018 Jul-Aug;12(4):849-856. doi: 10.1016/j.jacl.2018.04.001. Epub 2018 Apr 12. J Clin Lipidol. 2018. PMID: 29731282 Free PMC article. Review.
• Cyclodextrins: their future in drug formulation and delivery.
  Stella VJ, Rajewski RA. Stella VJ, et al. Pharm Res. 1997 May;14(5):556-67. doi: 10.1023/a:1012136608249. Pharm Res. 1997. PMID: 9165524 Review.
• Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers.
  Bouhnik Y, Achour L, Paineau D, Riottot M, Attar A, Bornet F. Bouhnik Y, et al. Nutr J. 2007 Dec 5;6:42. doi: 10.1186/1475-2891-6-42. Nutr J. 2007. PMID: 18053236 Free PMC article.

References

1. 1. J Lipid Res. 1965 Jul;6:397-410 - PubMed
2. 1. Arterioscler Thromb. 1991 Sep-Oct;11(5):1204-8 - PubMed
3. 1. Chem Pharm Bull (Tokyo). 1986 Mar;34(3):1395-8 - PubMed
4. 1. Dig Dis. 1987;5(2):65-77 - PubMed
5. 1. Lipids. 1976 Dec;11(12):845-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information