DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor - PubMed (original) (raw)
. 1993 Apr 2;260(5104):58-63.
doi: 10.1126/science.8465201.
Affiliations
- PMID: 8465201
- DOI: 10.1126/science.8465201
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor
L Schaeffer et al. Science. 1993.
Abstract
The human BTF2 basic transcription factor (also called TFIIH), which is similar to the delta factor in rat and factor b in yeast, is required for class II gene transcription. A strand displacement assay was used to show that highly purified preparation of BTF2 had an adenosine triphosphate-dependent DNA helicase activity, in addition to the previously characterized carboxyl-terminal domain kinase activity. Amino acid sequence analysis of the tryptic digest generated from the 89-kilodalton subunit of BTF2 indicated that this polypeptide corresponded to the ERCC-3 gene product, a presumed helicase implicated in the human DNA excision repair disorders xeroderma pigmentosum and Cockayne's syndrome. These findings suggest that transcription and nucleotide excision repair may share common factors and hence may be considered to be functionally related.
Comment in
- DNA repair and transcription: the helicase connection.
Buratowski S. Buratowski S. Science. 1993 Apr 2;260(5104):37-8. doi: 10.1126/science.8465198. Science. 1993. PMID: 8465198 No abstract available.
Similar articles
- A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
Hwang JR, Moncollin V, Vermeulen W, Seroz T, van Vuuren H, Hoeijmakers JH, Egly JM. Hwang JR, et al. J Biol Chem. 1996 Jul 5;271(27):15898-904. doi: 10.1074/jbc.271.27.15898. J Biol Chem. 1996. PMID: 8663148 - TFIIH: a link between transcription, DNA repair and cell cycle regulation.
Seroz T, Hwang JR, Moncollin V, Egly JM. Seroz T, et al. Curr Opin Genet Dev. 1995 Apr;5(2):217-21. doi: 10.1016/0959-437x(95)80011-5. Curr Opin Genet Dev. 1995. PMID: 7613092 Review. - Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.
Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D. Drapkin R, et al. Nature. 1994 Apr 21;368(6473):769-72. doi: 10.1038/368769a0. Nature. 1994. PMID: 8152490 - The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
Schaeffer L, Moncollin V, Roy R, Staub A, Mezzina M, Sarasin A, Weeda G, Hoeijmakers JH, Egly JM. Schaeffer L, et al. EMBO J. 1994 May 15;13(10):2388-92. doi: 10.1002/j.1460-2075.1994.tb06522.x. EMBO J. 1994. PMID: 8194528 Free PMC article. - The multiple roles of transcription/repair factor TFIIH.
Svejstrup JQ, Vichi P, Egly JM. Svejstrup JQ, et al. Trends Biochem Sci. 1996 Sep;21(9):346-50. Trends Biochem Sci. 1996. PMID: 8870499 Review.
Cited by
- Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
Theil AF, Nonnekens J, Steurer B, Mari PO, de Wit J, Lemaitre C, Marteijn JA, Raams A, Maas A, Vermeij M, Essers J, Hoeijmakers JH, Giglia-Mari G, Vermeulen W. Theil AF, et al. PLoS Genet. 2013 Apr;9(4):e1003431. doi: 10.1371/journal.pgen.1003431. Epub 2013 Apr 18. PLoS Genet. 2013. PMID: 23637614 Free PMC article. - TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription.
Singh A, Compe E, Le May N, Egly JM. Singh A, et al. Am J Hum Genet. 2015 Feb 5;96(2):194-207. doi: 10.1016/j.ajhg.2014.12.012. Epub 2015 Jan 22. Am J Hum Genet. 2015. PMID: 25620205 Free PMC article. - The Transition of Poised RNA Polymerase II to an Actively Elongating State Is a "Complex" Affair.
Yearling MN, Radebaugh CA, Stargell LA. Yearling MN, et al. Genet Res Int. 2011;2011:206290. doi: 10.4061/2011/206290. Epub 2011 Oct 12. Genet Res Int. 2011. PMID: 22567346 Free PMC article. - BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.
Takeda S, Tadele Z, Hofmann I, Probst AV, Angelis KJ, Kaya H, Araki T, Mengiste T, Mittelsten Scheid O, Shibahara K, Scheel D, Paszkowski J. Takeda S, et al. Genes Dev. 2004 Apr 1;18(7):782-93. doi: 10.1101/gad.295404. Genes Dev. 2004. PMID: 15082530 Free PMC article. - Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.
Pannucci NL, Li D, Sahay S, Thomas EK, Chen R, Tala I, Hu T, Ciccarelli BT, Megjugorac NJ, Adams Iii HC, Rodriguez PL, Fitzpatrick ER, Lagunoff D, Williams DA, Whitehead IP. Pannucci NL, et al. Blood Cancer J. 2013 Aug 16;3(8):e135. doi: 10.1038/bcj.2013.36. Blood Cancer J. 2013. PMID: 23955590 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials