Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells - PubMed (original) (raw)
. 1993 Apr 15;53(8):1735-8.
Affiliations
- PMID: 8467488
Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells
C A Evans et al. Cancer Res. 1993.
Abstract
A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Philadelphia chromosome. The BRC-ABL protein displays an uncontrolled tyrosine kinase activity similar to that seen with the transforming oncogene of the Abelson murine leukemia (ABL) virus (v-abl). An interleukin 3 dependent cell line, IC.DP, has been transfected with a gene encoding a temperature sensitive v-ABL. In the absence of interleukin 3 at the restrictive temperature for ABL tyrosine kinase activity IC.DP cells died via apoptosis. At the permissive temperature ABL tyrosine kinase activity promoted IC.DP cell survival but not proliferation. ABL therefore can specifically suppress apoptosis.
Similar articles
- The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.
Chapman RS, Whetton AD, Dive C. Chapman RS, et al. Cancer Res. 1994 Oct 1;54(19):5131-7. Cancer Res. 1994. PMID: 7923130 - v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL.
Chen Q, Turner J, Watson AJ, Dive C. Chen Q, et al. Oncogene. 1997 Oct;15(18):2249-54. doi: 10.1038/sj.onc.1201371. Oncogene. 1997. PMID: 9393984 - Inhibition of Abelson oncogene function by erbstatin analogues.
Kawada M, Tawara J, Tsuji T, Honma Y, Hozumi M, Wang JY, Umezawa K. Kawada M, et al. Drugs Exp Clin Res. 1993;19(6):235-41. Drugs Exp Clin Res. 1993. PMID: 8013266 Review. - Transforming pathways activated by the v-Abl tyrosine kinase.
Shore SK, Tantravahi RV, Reddy EP. Shore SK, et al. Oncogene. 2002 Dec 9;21(56):8568-76. doi: 10.1038/sj.onc.1206084. Oncogene. 2002. PMID: 12476303 Review.
Cited by
- Apoptosis: Molecular mechanisms, regulation and role in pathogenesis.
Hung RW, Chow AW. Hung RW, et al. Can J Infect Dis. 1997 Mar;8(2):103-9. doi: 10.1155/1997/131305. Can J Infect Dis. 1997. PMID: 22514484 Free PMC article. - Role of protein kinase activity in apoptosis.
Lavin MF, Watters D, Song Q. Lavin MF, et al. Experientia. 1996 Oct 31;52(10-11):979-94. doi: 10.1007/BF01920107. Experientia. 1996. PMID: 8917729 Review. - Apoptosis in Endocrine Glands.
Kontogeorgos G, Kovacs K. Kontogeorgos G, et al. Endocr Pathol. 1995 Winter;6(4):257-265. doi: 10.1007/BF02738726. Endocr Pathol. 1995. PMID: 12114808 - The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.
Neshat MS, Raitano AB, Wang HG, Reed JC, Sawyers CL. Neshat MS, et al. Mol Cell Biol. 2000 Feb;20(4):1179-86. doi: 10.1128/MCB.20.4.1179-1186.2000. Mol Cell Biol. 2000. PMID: 10648603 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous