Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype - PubMed (original) (raw)
Affiliations
- PMID: 8468527
Free article
Clinical Trial
Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype
L J Martin et al. J Lipid Res. 1993 Mar.
Free article
Abstract
The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins. We have determined the effects of apoE genotype on the plasma lipoprotein response to cholesterol feeding in 30 young normal male subjects (5 E3/2, 11 E3/3, 14 E4/3) under rigorously controlled dietary conditions. Two diets, differing only in cholesterol content (low cholesterol (LC): 80 mg cholesterol/1000 kcal and high cholesterol (HC): 320 mg cholesterol/1000 kcal), were compared using a random crossover design. At the end of the HC as compared to the LC period, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and HDL2-C increased by an average of 15%, 21%, 7%, and 23%, respectively, for the three genotype groups combined (P < 0.001 for each). The LDL-C response to dietary cholesterol did not differ among the apoE genotypes. However, the increase in HDL-C varied significantly according to the apoE genotype (E3/2: 0 change, E3/3: +4%, E4/3: +12%; P < 0.05). The plasma cholesteryl ester transfer protein (CETP) response to cholesterol feeding also differed amongst the three apoE genotype groups (E3/2: +37%, E3/3: +18%, E4/3: +9%) (P < 0.05). ApoE genotype has significant and opposite effects on plasma CETP and HDL-C responses to dietary cholesterol in men.
Similar articles
- Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype.
Wilund KR, Ferrell RE, Phares DA, Goldberg AP, Hagberg JM. Wilund KR, et al. Metabolism. 2002 Jun;51(6):774-8. doi: 10.1053/meta.2002.32730. Metabolism. 2002. PMID: 12037734 Clinical Trial. - Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes.
Dullaart RP, Hoogenberg K, Riemens SC, Groener JE, van Tol A, Sluiter WJ, Stulp BK. Dullaart RP, et al. Diabetes. 1997 Dec;46(12):2082-7. doi: 10.2337/diab.46.12.2082. Diabetes. 1997. PMID: 9392500 Clinical Trial. - Quantitative and compositional changes in high density lipoprotein subclasses in patients with various genotypes of cholesteryl ester transfer protein deficiency.
Chiba H, Akita H, Tsuchihashi K, Hui SP, Takahashi Y, Fuda H, Suzuki H, Shibuya H, Tsuji M, Kobayashi K. Chiba H, et al. J Lipid Res. 1997 Jun;38(6):1204-16. J Lipid Res. 1997. PMID: 9215548 - Dietary fat and carbohydrate affect the metabolism of protein-based high-density lipoprotein subspecies.
Sacks FM, Andraski AB. Sacks FM, et al. Curr Opin Lipidol. 2022 Feb 1;33(1):1-15. doi: 10.1097/MOL.0000000000000809. Curr Opin Lipidol. 2022. PMID: 34907968 Free PMC article. Review.
Cited by
- Quantitation of anacetrapib in human and animal adipose by liquid chromatography with mass spectrometric detection.
Fang W, Chavez-Eng CM, Lutz RW, Li H, Schlegel J, Roadcap B, Schiller J, Woolf E. Fang W, et al. Bioanalysis. 2024;16(16):863-871. doi: 10.1080/17576180.2024.2376427. Epub 2024 Aug 9. Bioanalysis. 2024. PMID: 39119687 - Profound Elevation in LDL Cholesterol Level Following a Ketogenic Diet: A Case Series.
Crosier R, McPherson R. Crosier R, et al. CJC Open. 2022 Jun 9;4(8):732-734. doi: 10.1016/j.cjco.2022.05.001. eCollection 2022 Aug. CJC Open. 2022. PMID: 36035741 Free PMC article. - Modification of High-Density Lipoprotein Functions by Diet and Other Lifestyle Changes: A Systematic Review of Randomized Controlled Trials.
Sanllorente A, Lassale C, Soria-Florido MT, Castañer O, Fitó M, Hernáez Á. Sanllorente A, et al. J Clin Med. 2021 Dec 15;10(24):5897. doi: 10.3390/jcm10245897. J Clin Med. 2021. PMID: 34945193 Free PMC article. Review. - A Population Pharmacokinetic and Pharmacodynamic Model of CKD-519.
Kim CO, Jeon S, Han S, Park MS, Yim DS. Kim CO, et al. Pharmaceutics. 2020 Jun 19;12(6):573. doi: 10.3390/pharmaceutics12060573. Pharmaceutics. 2020. PMID: 32575566 Free PMC article. - Molecular Pathways Underlying Cholesterol Homeostasis.
Afonso MS, Machado RM, Lavrador MS, Quintao ECR, Moore KJ, Lottenberg AM. Afonso MS, et al. Nutrients. 2018 Jun 13;10(6):760. doi: 10.3390/nu10060760. Nutrients. 2018. PMID: 29899250 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous