Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells - PubMed (original) (raw)
. 1993 Apr 22;362(6422):758-61.
doi: 10.1038/362758a0.
Affiliations
- PMID: 8469287
- DOI: 10.1038/362758a0
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
D Moskophidis et al. Nature. 1993.
Erratum in
- Nature 1993 Jul 15;364(6434):262
Abstract
Viruses that are non- or poorly cytopathic have developed various strategies to avoid elimination by the immune system and to persist in the host. Acute infection of adult mice with the noncytopathic lymphocytic choriomeningitis virus (LCMV) normally induces a protective cytotoxic T-cell response that also causes immunopathology. But some LCMV strains (such as DOCILE (LCMV-D) or Cl-13 Armstrong (Cl-13)) derived from virus carrier mice tend to persist after acute infection of adult mice without causing lethal immunopathological disease. Tendency to persist correlates with tropism, rapidity of virus spread and virus mutations. We report here that these LCMV isolates may persist because they induce most of the specific antiviral CD8+ cytotoxic T cells so completely that they all disappear within a few days and therefore neither eliminate the virus nor cause lethal immunopathology. The results illustrate that partially and sequentially induced (protective) immunity or complete exhaustion of T-cell immunity (high zone tolerance) are quantitatively different points on the scale of immunity; some viruses exploit the latter possibility to persist in an immunocompetent host.
Comment in
- Immunology. Tolerance by exhaustion.
von Boehmer H. von Boehmer H. Nature. 1993 Apr 22;362(6422):696. doi: 10.1038/362696a0. Nature. 1993. PMID: 8469279 No abstract available.
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