A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs - PubMed (original) (raw)

A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs

O Bezzubova et al. Nucleic Acids Res. 1993.

Free PMC article

Abstract

Comparisons of the amino acid sequences of three yeast RecA-like proteins, Rad51 and DMC1 from S.cerevisiae and Rad51 from S.pombe, revealed several highly conserved regions. Degenerated oligonucleotides encoding two of these regions were used for the polymerase chain reaction to clone a chicken RecA-like gene. The encoded protein shares 68% and 49% identical amino acids with the Rad51 and DMC1 proteins. The strong sequence conservation between the yeast and chicken genes indicates that RecA homologues are conserved throughout evolution from prokaryotes to higher eukaryotes. High expression of the chicken Rad51 gene was found within the organs of lymphoid and germ cell development suggesting its involvement in lymphoid and meiotic recombination.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1965 Sep;54(3):864-9 - PubMed
    1. Mutat Res. 1980 Dec;73(2):251-65 - PubMed
    1. Mol Gen Genet. 1981;182(2):196-205 - PubMed
    1. Nature. 1983 Apr 14;302(5909):575-81 - PubMed
    1. Cell. 1983 Nov;35(1):167-74 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources