The innervation of human epidermis - PubMed (original) (raw)
The innervation of human epidermis
W R Kennedy et al. J Neurol Sci. 1993 Apr.
Abstract
Using immunohistochemical procedures numerous nerve fibers have been found in all cell layers of human epidermis. These nerves originate from nerve trunks in the dermis, enter the epidermis, then divide distally to eventually end in small enlargements, near the surface of the skin and in deeper areas. Some endings may be external to stratum granulosum cells. Epidermal nerves appear to have a three-dimensional territorial distribution in relationship to the skin's surface. The presence of epidermal nerve fibers was confirmed by electron microscope studies. The nerves are presumed to be sensory in nature. The existence of epidermal nerve fibers will necessitate changes in present theory of structure and function of peripheral sensation.
Comment in
- The innervation of the human epidermis.
Johansson O. Johansson O. J Neurol Sci. 1995 Jun;130(2):228. doi: 10.1016/0022-510x(95)00097-l. J Neurol Sci. 1995. PMID: 8586992 No abstract available.
Similar articles
- Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study.
Navarro X, Verdú E, Wendelscafer-Crabb G, Kennedy WR. Navarro X, et al. J Neurosci Res. 1995 May 1;41(1):111-20. doi: 10.1002/jnr.490410113. J Neurosci Res. 1995. PMID: 7545760 - Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function.
Simone DA, Nolano M, Johnson T, Wendelschafer-Crabb G, Kennedy WR. Simone DA, et al. J Neurosci. 1998 Nov 1;18(21):8947-59. doi: 10.1523/JNEUROSCI.18-21-08947.1998. J Neurosci. 1998. PMID: 9787000 Free PMC article. - Epidermal innervation in diabetes.
Ebenezer G, Polydefkis M. Ebenezer G, et al. Handb Clin Neurol. 2014;126:261-74. doi: 10.1016/B978-0-444-53480-4.00020-5. Handb Clin Neurol. 2014. PMID: 25410228 Review. - The epidermis: a sensory tissue.
Boulais N, Misery L. Boulais N, et al. Eur J Dermatol. 2008 Mar-Apr;18(2):119-27. doi: 10.1684/ejd.2008.0348. Eur J Dermatol. 2008. PMID: 18424369 Review.
Cited by
- Discontinuity third harmonic generation microscopy for label-free imaging and quantification of intraepidermal nerve fibers.
Wu PJ, Tseng HC, Chao CC, Liao YH, Yen CT, Lin WY, Hsieh ST, Sun WZ, Sun CK. Wu PJ, et al. Cell Rep Methods. 2024 Mar 25;4(3):100735. doi: 10.1016/j.crmeth.2024.100735. Epub 2024 Mar 18. Cell Rep Methods. 2024. PMID: 38503290 Free PMC article. - Sensorized Skin With Biomimetic Tactility Features Based on Artificial Cross-Talk of Bimodal Resistive Sensory Inputs.
Georgopoulou A, Hardman D, Thuruthel TG, Iida F, Clemens F. Georgopoulou A, et al. Adv Sci (Weinh). 2023 Oct;10(30):e2301590. doi: 10.1002/advs.202301590. Epub 2023 Sep 7. Adv Sci (Weinh). 2023. PMID: 37679081 Free PMC article. - Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy.
Raicher I, Ravagnani LHC, Correa SG, Dobo C, Mangueira CLP, Macarenco RSES. Raicher I, et al. Einstein (Sao Paulo). 2022 Jul 8;20:eMD8044. doi: 10.31744/einstein_journal/2022MD8044. eCollection 2022. Einstein (Sao Paulo). 2022. PMID: 35830153 Free PMC article. - Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness.
Albrecht PJ, Houk G, Ruggiero E, Dockum M, Czerwinski M, Betts J, Wymer JP, Argoff CE, Rice FL. Albrecht PJ, et al. Front Pain Res (Lausanne). 2021 Dec 8;2:790524. doi: 10.3389/fpain.2021.790524. eCollection 2021. Front Pain Res (Lausanne). 2021. PMID: 35295428 Free PMC article. - Serpinin in the Skin.
Fraquelli C, Hauzinger J, Humpel C, Nolano M, Provitera V, Sharma VK, Loh P, Pidsudko Z, Blatsios G, Troger J. Fraquelli C, et al. Biomedicines. 2022 Jan 16;10(1):183. doi: 10.3390/biomedicines10010183. Biomedicines. 2022. PMID: 35052862 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources