GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons - PubMed (original) (raw)

Comment

. 1993 May 21;260(5111):1130-2.

doi: 10.1126/science.8493557.

Affiliations

• PMID: 8493557
• DOI: 10.1126/science.8493557

Comment

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

L F Lin et al. Science. 1993.

Abstract

A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

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Comment on

• Promising protein for Parkinson's.
  Weiss R. Weiss R. Science. 1993 May 21;260(5111):1072-3. doi: 10.1126/science.8493547. Science. 1993. PMID: 8493547 No abstract available.

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