Relation of phenotype evolution of HIV-1 to envelope V2 configuration - PubMed (original) (raw)
. 1993 Jun 4;260(5113):1513-6.
doi: 10.1126/science.8502996.
Affiliations
- PMID: 8502996
- DOI: 10.1126/science.8502996
Relation of phenotype evolution of HIV-1 to envelope V2 configuration
M Groenink et al. Science. 1993.
Abstract
Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp120 contained the major determinants of SI capacity. The configuration of a hypervariable locus in the V2 domain appeared to be predictive for non-SI to SI phenotype conversion. Early prediction of HIV-1 phenotype evolution may be useful for clinical monitoring and treatment of asymptomatic infection.
Comment in
- Envelope V2 configuration and HIV-1 phenotype: clarification.
Schuitemaker H, Fouchier RA, Broersen S, Groenink M, Koot M, van 't Wout AB, Huisman HG, Tersmette M, Miedema F. Schuitemaker H, et al. Science. 1995 Apr 7;268(5207):115. doi: 10.1126/science.7755774. Science. 1995. PMID: 7755774 No abstract available.
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