Intestinal mucosal inflammation associated with human immunodeficiency virus infection - PubMed (original) (raw)

Comparative Study

. 1993 Jun;38(6):1119-27.

doi: 10.1007/BF01295730.

Affiliations

Comparative Study

Intestinal mucosal inflammation associated with human immunodeficiency virus infection

D P Kotler et al. Dig Dis Sci. 1993 Jun.

Abstract

The role of the human immunodeficiency virus type-1 (HIV) in producing intestinal disease was studied prospectively in 74 HIV-infected individuals with (43) or without (31) the acquired immunodeficiency syndrome (AIDS). Thirty-one subjects had enteric infections; all but one had AIDS. Alteration in bowel habits was the most common symptom and occurred independently of enteric infections. Abnormal histopathology was present in 69% of cases, and the finding was associated with altered bowel habits. An HIV-associated protein, p24, was detected in 71% of biopsies by ELISA assay. Tissue p24 contents varied with disease stage and were highest in HIV-infected individuals without AIDS (Walter Reed classes 3 and 4). Tissue p24 detection was associated with both altered bowel habits and histologic mucosal abnormalities. Tissue contents of the cytokines, tumor necrosis factor-alpha and interleukin-1 beta, were higher in HIV-infected individuals than in controls and their elevations were independent of enteric infection. We conclude that HIV reactivation in the intestinal mucosa may be associated with an inflammatory bowel syndrome in the absence of other enteric pathogens.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Nature. 1987 Jul 23-29;328(6128):345-8 - PubMed
    1. AIDS Res Hum Retroviruses. 1989 Feb;5(1):1-4 - PubMed
    1. AIDS. 1989 Nov;3(11):695-9 - PubMed
    1. J Infect Dis. 1989 Mar;159(3):467-71 - PubMed
    1. J Immunol. 1986 Jun 1;136(11):4049-53 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources