Crystal structure of cyclin-dependent kinase 2 - PubMed (original) (raw)

. 1993 Jun 17;363(6430):595-602.

doi: 10.1038/363595a0.

Affiliations

• PMID: 8510751
• DOI: 10.1038/363595a0

Crystal structure of cyclin-dependent kinase 2

H L De Bondt et al. Nature. 1993.

Abstract

Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.

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