Segmental organization of embryonic diencephalon - PubMed (original) (raw)
. 1993 Jun 17;363(6430):630-4.
doi: 10.1038/363630a0.
Affiliations
- PMID: 8510755
- DOI: 10.1038/363630a0
Segmental organization of embryonic diencephalon
M C Figdor et al. Nature. 1993.
Abstract
The diencephalon is a complex integration centre and intricate relay station of the vertebrate brain. Its development involves the generation of great cellular diversity and neuronal specificity. We report here that it becomes organized in steps, through a stereotyped sequence of neuromeric subdivisions. Diencephalic neuromeres define four cellular domains (D1-D4) that can be followed throughout development, each unit contributing to a well defined part of the adult structural pattern. We propose that the segmental identity of each diencephalic unit is specified by a unique combination of genes, maintained by polyclonal cell lineage restrictions. A comparison of vertebrate and arthropod development suggests that the basic principles that control anterior axial patterning and set up neuronal specificity in the embryonic central nervous system are highly conserved in evolution.
Similar articles
- Fate map of the diencephalon and the zona limitans at the 10-somites stage in chick embryos.
Garcia-Lopez R, Vieira C, Echevarria D, Martinez S. Garcia-Lopez R, et al. Dev Biol. 2004 Apr 15;268(2):514-30. doi: 10.1016/j.ydbio.2003.12.038. Dev Biol. 2004. PMID: 15063186 - Patterning the developing diencephalon.
Lim Y, Golden JA. Lim Y, et al. Brain Res Rev. 2007 Jan;53(1):17-26. doi: 10.1016/j.brainresrev.2006.06.004. Epub 2006 Jul 31. Brain Res Rev. 2007. PMID: 16876871 Review. - Early diencephalon development in Alligator.
Pritz MB. Pritz MB. Brain Behav Evol. 2008;71(1):15-31. doi: 10.1159/000108608. Epub 2007 Sep 20. Brain Behav Evol. 2008. PMID: 17878715 - Neuroblast formation and patterning during early brain development in Drosophila.
Urbach R, Technau GM. Urbach R, et al. Bioessays. 2004 Jul;26(7):739-51. doi: 10.1002/bies.20062. Bioessays. 2004. PMID: 15221856 Review. - Sonic hedgehog from the basal plate and the zona limitans intrathalamica exhibits differential activity on diencephalic molecular regionalization and nuclear structure.
Vieira C, Martinez S. Vieira C, et al. Neuroscience. 2006 Nov 17;143(1):129-40. doi: 10.1016/j.neuroscience.2006.08.032. Epub 2006 Oct 10. Neuroscience. 2006. PMID: 17045408
Cited by
- Phylogeny and ontogeny of the habenular structure.
Aizawa H, Amo R, Okamoto H. Aizawa H, et al. Front Neurosci. 2011 Dec 21;5:138. doi: 10.3389/fnins.2011.00138. eCollection 2011. Front Neurosci. 2011. PMID: 22203792 Free PMC article. - Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.
Puelles E, Acampora D, Gogoi R, Tuorto F, Papalia A, Guillemot F, Ang SL, Simeone A. Puelles E, et al. J Neurosci. 2006 May 31;26(22):5955-64. doi: 10.1523/JNEUROSCI.1097-06.2006. J Neurosci. 2006. PMID: 16738237 Free PMC article. - Blocking N-cadherin function disrupts the epithelial structure of differentiating neural tissue in the embryonic chicken brain.
Gänzler-Odenthal SI, Redies C. Gänzler-Odenthal SI, et al. J Neurosci. 1998 Jul 15;18(14):5415-25. doi: 10.1523/JNEUROSCI.18-14-05415.1998. J Neurosci. 1998. PMID: 9651223 Free PMC article. - A 7-base-pair sequence protects DNA from exonucleolytic degradation in Lactococcus lactis.
Biswas I, Maguin E, Ehrlich SD, Gruss A. Biswas I, et al. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2244-8. doi: 10.1073/pnas.92.6.2244. Proc Natl Acad Sci U S A. 1995. PMID: 7892255 Free PMC article. - Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling.
Peukert D, Weber S, Lumsden A, Scholpp S. Peukert D, et al. PLoS Biol. 2011 Dec;9(12):e1001218. doi: 10.1371/journal.pbio.1001218. Epub 2011 Dec 13. PLoS Biol. 2011. PMID: 22180728 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources