Molecular cloning of an apolipoprotein B messenger RNA editing protein - PubMed (original) (raw)

. 1993 Jun 18;260(5115):1816-9.

doi: 10.1126/science.8511591.

Affiliations

• PMID: 8511591
• DOI: 10.1126/science.8511591

Molecular cloning of an apolipoprotein B messenger RNA editing protein

B Teng et al. Science. 1993.

Abstract

Mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene. The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine deamination produces a UAA termination codon. A full-length complementary DNA clone encoding an apo B messenger RNA editing protein (REPR) was isolated from rat small intestine. The 229-residue protein contains consensus phosphorylation sites and leucine zipper domains. HepG2 cell extracts acquire editing activity when mixed with REPR from oocyte extracts. REPR is essential for apo B messenger RNA editing, and the isolation and characterization of REPR may lead to the identification of other eukaryotic RNA editing proteins.

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