DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces - PubMed (original) (raw)
Affiliations
- PMID: 8513150
Review
DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces
J C Game. Semin Cancer Biol. 1993 Apr.
Abstract
The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence of repair a single break may be lethal to the cell. Genetic and molecular analysis of the eight genes known as RAD50 to RAD57 has revealed much about recombinational repair. These genes are also of central importance in other processes including meiosis and may be of general significance in understanding radiation responses in eukaryotes.
Similar articles
- [Molecular-genetic analysis of dual-stranded DNA break repair in saccharomyces yeasts].
Glazer VM, Glazunov AV. Glazer VM, et al. Genetika. 1999 Nov;35(11):1449-69. Genetika. 1999. PMID: 10624571 Review. Russian. - [Disorder of the repair of DNA double-stranded breaks in radiosensitive mutants of Saccharomyces cerevisiae yeasts].
Vishnevetskaia OIu, Luchnik AN, Arutiunova LS, Shestakov SV. Vishnevetskaia OIu, et al. Genetika. 1983;19(1):26-32. Genetika. 1983. PMID: 6339317 Russian. - DNA lesions that signal the induction of radioresistance and DNA repair in yeast.
Boreham DR, Mitchel RE. Boreham DR, et al. Radiat Res. 1991 Oct;128(1):19-28. Radiat Res. 1991. PMID: 1924725 - Two pathways of DNA double-strand break repair in G1 cells of Saccharomyces cerevisiae.
Glasunov AV, Glaser VM, Kapultsevich YG. Glasunov AV, et al. Yeast. 1989 Mar-Apr;5(2):131-9. doi: 10.1002/yea.320050208. Yeast. 1989. PMID: 2652919 - [The role of the repair of double-stranded DNA breaks in the radioresistance of yeast cells].
Glazunov AV. Glazunov AV. Radiobiologiia. 1990 Jan-Feb;30(1):3-15. Radiobiologiia. 1990. PMID: 2179984 Review. Russian.
Cited by
- Protein fluorescent labeling in live yeast cells using scFv-based probes.
Tsirkas I, Zur T, Dovrat D, Cohen A, Ravkaie L, Aharoni A. Tsirkas I, et al. Cell Rep Methods. 2022 Dec 6;2(12):100357. doi: 10.1016/j.crmeth.2022.100357. eCollection 2022 Dec 19. Cell Rep Methods. 2022. PMID: 36590693 Free PMC article. - Comparative analysis of transcriptional profiles of Schistosoma japonicum adult worms derived from primary-infected and re-infected water buffaloes.
Mao Y, He C, Li H, Lu K, Fu Z, Hong Y, Jin Y, Lin J, Zhang X, Liu J. Mao Y, et al. Parasit Vectors. 2019 Jul 11;12(1):340. doi: 10.1186/s13071-019-3600-y. Parasit Vectors. 2019. PMID: 31296252 Free PMC article. - The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.
Zhao W, Wiese C, Kwon Y, Hromas R, Sung P. Zhao W, et al. Annu Rev Biochem. 2019 Jun 20;88:221-245. doi: 10.1146/annurev-biochem-013118-111058. Epub 2019 Mar 27. Annu Rev Biochem. 2019. PMID: 30917004 Free PMC article. Review. - MiRNA-binding site functional polymorphisms in DNA repair genes RAD51, RAD52, and XRCC2 and breast cancer risk in Chinese population.
Cao J, Luo C, Peng R, Guo Q, Wang K, Wang P, Ye H, Song C. Cao J, et al. Tumour Biol. 2016 Oct 10. doi: 10.1007/s13277-016-5459-2. Online ahead of print. Tumour Biol. 2016. PMID: 27726100 - Chromatin immunoprecipitation to detect DNA replication and repair factors.
Gadaleta MC, Iwasaki O, Noguchi C, Noma K, Noguchi E. Gadaleta MC, et al. Methods Mol Biol. 2015;1300:169-86. doi: 10.1007/978-1-4939-2596-4_12. Methods Mol Biol. 2015. PMID: 25916713 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Research Materials
Miscellaneous