A molecular variant of angiotensinogen associated with preeclampsia - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ng0593-59.
Affiliations
- PMID: 8513325
- DOI: 10.1038/ng0593-59
Comparative Study
A molecular variant of angiotensinogen associated with preeclampsia
K Ward et al. Nat Genet. 1993 May.
Abstract
Pregnancy-induced hypertension (PIH) is a heterogeneous disorder which complicates 5-7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life-threatening form; a multi-system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy-induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.
Comment in
- Angiotensinogen: a candidate gene involved in preeclampsia?
Arngrímsson R, Purandare S, Connor M, Walker JJ, Björnsson S, Soubrier F, Kotelevtsev YV, Geirsson RT, Björnsson H. Arngrímsson R, et al. Nat Genet. 1993 Jun;4(2):114-5. doi: 10.1038/ng0693-114. Nat Genet. 1993. PMID: 8348146 No abstract available. - Genes, phenotypes and hypertensive pregnancies.
Graves SW, Seely EW, Williams GH. Graves SW, et al. Nat Genet. 1993 May;4(1):7-8. doi: 10.1038/ng0593-7. Nat Genet. 1993. PMID: 8513328 No abstract available.
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