Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM - PubMed (original) (raw)

Review

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

T Enoch et al. Trends Biochem Sci. 1995 Oct.

Abstract

'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell 'choose' between cycle arrest and death? Analysis of two human tumour suppressor proteins, p53 and the ATM (ataxia-telangiectasia mutated) gene product, may provide some answers.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal