Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro - PubMed (original) (raw)
Comparative Study
. 1995 Aug;36(6):1127-33.
Affiliations
- PMID: 8535283
Comparative Study
Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro
L De Petrocellis et al. Biochem Mol Biol Int. 1995 Aug.
Abstract
Anandamide (AnNH, N-arachidonoyl-ethanolamine) has been recently proposed as the endogenous ligand for mammalian brain cannabinoid receptor. Non-cannabinoid receptor-mediated, intracellular actions have been also found for this novel mediator. Here we present evidence for the modulation by anandamide of rat brain protein kinase C (PKC) activity in vitro. The ethanolamide of arachidonic acid (AA) was more active than the free acid in increasing phosphatidylserine (PS)-induced PKC activation (EC50 = 40 microM), but inhibited dioleylglycerol-induced potentiation of both Ca(2+)- and Ca2+/PS-induced PKC activation (IC50 = 8 microM and 30 microM, respectively). A dual modulatory action of anandamide on PKC, exerted by binding to the diacylglycerol regulatory site, is hypothesized in rat brain.
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