Common genetic influences on BMI and age at menarche - PubMed (original) (raw)
Affiliations
- PMID: 8543288
Common genetic influences on BMI and age at menarche
J Kaprio et al. Hum Biol. 1995 Oct.
Abstract
Genetic influences on variability of body weight and onset of menarche are well known. To investigate the genetic and environmental contributions to the association of body weight with onset of menarche, we studied Finnish twins from consecutive birth cohorts (the FinnTwin16 study) ascertained from the national population registry, which identifies nearly 100% of all living twins. Baseline questionnaires were mailed to the twins within 60 days of their sixteenth birthday and later to older sibs of the twins. Pairwise response rates (approximately 85% across gender and zygosity) and 30 months of data collection yielded results from 1283 twin pairs. The questionnaires included a survey of health habits and attitudes, a symptom checklist, MMPI personality scales, and a survey of relationships with parents, peers, and the co-twin. Age at menarche was reported by 468 monozygotic (MZ) girls, 378 girls from like-sex dizygotic (FDZ) pairs, 434 girls from opposite-sex (OSDZ) pairs, and 141 older female sibs of the twins. The one-month test-retest reliability of age at menarche in an independent sample (N = 136) of 16-year-olds from a national survey was 0.96. Girls from OSDZ pairs had a significantly higher mean age at menarche (13.33 yr) than FDZ girls (13.13 yr) (difference, 0.20 yr; 95% confidence interval, 0.05-0.35). The MZ correlation for age at menarche was 0.75, the DZ correlation was 0.31, and the sib-twin correlation was 0.32. A bivariate twin analysis of age at menarche and body mass index (wt/ht2) indicated that 37% of the variance in age at menarche can be attributed to additive genetic effects, 37% to dominance effects, and 26% to unique environmental effects. The correlation between additive genetic effects on age at menarche and body mass index was 0.57, indicating a substantial proportion of genetic effects in common.
Similar articles
- Consistency and change of body mass index and weight. A study on 5967 adult Finnish twin pairs.
Korkeila M, Kaprio J, Rissanen A, Koskenvuo M. Korkeila M, et al. Int J Obes Relat Metab Disord. 1995 May;19(5):310-7. Int J Obes Relat Metab Disord. 1995. PMID: 7647822 - Genetic and environmental influences on the tracking of body size from birth to early adulthood.
Pietiläinen KH, Kaprio J, Räsänen M, Rissanen A, Rose RJ. Pietiläinen KH, et al. Obes Res. 2002 Sep;10(9):875-84. doi: 10.1038/oby.2002.120. Obes Res. 2002. PMID: 12226135 - Widespread pain among 11-year-old Finnish twin pairs.
Mikkelsson M, Kaprio J, Salminen JJ, Pulkkinen L, Rose RJ. Mikkelsson M, et al. Arthritis Rheum. 2001 Feb;44(2):481-5. doi: 10.1002/1529-0131(200102)44:2<481::AID-ANR68>3.0.CO;2-X. Arthritis Rheum. 2001. PMID: 11229481 - EEG sleep patterns in twins.
Linkowski P. Linkowski P. J Sleep Res. 1999 Jun;8 Suppl 1:11-3. doi: 10.1046/j.1365-2869.1999.00002.x. J Sleep Res. 1999. PMID: 10389101 Review. - Genetics, Genome-Wide Association Studies, and Menarche.
Witchel SF. Witchel SF. Semin Reprod Med. 2016 Jul;34(4):205-14. doi: 10.1055/s-0036-1585405. Epub 2016 Aug 11. Semin Reprod Med. 2016. PMID: 27513021 Review.
Cited by
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.
Tsinopoulou VR, Bacopoulou F, Fidani S, Christoforidis A. Tsinopoulou VR, et al. Hormones (Athens). 2024 Sep 4. doi: 10.1007/s42000-024-00594-3. Online ahead of print. Hormones (Athens). 2024. PMID: 39227549 Review. - Adolescents' height and cognitive ability in China.
Guo XH, Wang MY, Chou LC. Guo XH, et al. Heliyon. 2024 Mar 27;10(7):e28742. doi: 10.1016/j.heliyon.2024.e28742. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38590882 Free PMC article. - Reproductive risk factors across the female lifecourse and later metabolic health.
Nichols AR, Chavarro JE, Oken E. Nichols AR, et al. Cell Metab. 2024 Feb 6;36(2):240-262. doi: 10.1016/j.cmet.2024.01.002. Epub 2024 Jan 26. Cell Metab. 2024. PMID: 38280383 Review. - DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study.
Sehovic E, Zellers SM, Youssef MK, Heikkinen A, Kaprio J, Ollikainen M. Sehovic E, et al. Clin Epigenetics. 2023 Nov 10;15(1):181. doi: 10.1186/s13148-023-01594-7. Clin Epigenetics. 2023. PMID: 37950287 Free PMC article. - Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight.
Reshetnikova Y, Churnosova M, Stepanov V, Bocharova A, Serebrova V, Trifonova E, Ponomarenko I, Sorokina I, Efremova O, Orlova V, Batlutskaya I, Ponomarenko M, Churnosov V, Eliseeva N, Aristova I, Polonikov A, Reshetnikov E, Churnosov M. Reshetnikova Y, et al. Life (Basel). 2023 Jul 7;13(7):1525. doi: 10.3390/life13071525. Life (Basel). 2023. PMID: 37511900 Free PMC article.