The elevated plus-maze is not sensitive to the effect of stressor controllability in rats - PubMed (original) (raw)
The elevated plus-maze is not sensitive to the effect of stressor controllability in rats
R E Grahn et al. Pharmacol Biochem Behav. 1995 Nov.
Abstract
The present experiments examined the sensitivity of the elevated plus-maze to the effects of stressor controllability. Previous work had established that inescapable but not an equal amount of escapable electric tail shock reduced social interaction. The present experiments demonstrate that prior exposure to shock alters elevated plus-maze behavior, but that this effect is not sensitive to the escapability of the shock. These experiments include a replication of the usual pharmacologic effects of benzodiazepine ligands (2 mg/kg diazepam; 0.4 mg/kg methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) to demonstrate the sensitivity of the elevated plus-maze procedures used. The results provide additional support for the idea that the social interaction and elevated plus-maze measures of "anxiety" are sensitive to different processes.
Similar articles
- Fear-potentiation in the elevated plus-maze test depends on stressor controllability and fear conditioning.
Korte SM, De Boer SF, Bohus B. Korte SM, et al. Stress. 1999 Aug;3(1):27-40. doi: 10.3109/10253899909001110. Stress. 1999. PMID: 19016191 - Uncontrollable stress potentiates morphine's rewarding properties.
Will MJ, Watkins LR, Maier SF. Will MJ, et al. Pharmacol Biochem Behav. 1998 Jul;60(3):655-64. doi: 10.1016/s0091-3057(98)00027-6. Pharmacol Biochem Behav. 1998. PMID: 9678649 - Factors that modulate inescapable shock-induced reductions in daily activity in the rat.
Woodmansee WW, Silbert LH, Maier SF. Woodmansee WW, et al. Pharmacol Biochem Behav. 1993 Jul;45(3):553-9. doi: 10.1016/0091-3057(93)90505-n. Pharmacol Biochem Behav. 1993. PMID: 8392730 - A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze.
Korte SM, De Boer SF. Korte SM, et al. Eur J Pharmacol. 2003 Feb 28;463(1-3):163-75. doi: 10.1016/s0014-2999(03)01279-2. Eur J Pharmacol. 2003. PMID: 12600708 Review. - [Evaluation of anxiety-related behavior in elevated plus-maze test and its applications].
Yamaguchi T, Togashi H, Matsumoto M, Yoshioka M. Yamaguchi T, et al. Nihon Yakurigaku Zasshi. 2005 Aug;126(2):99-106. doi: 10.1254/fpj.126.99. Nihon Yakurigaku Zasshi. 2005. PMID: 16205011 Review. Japanese. No abstract available.
Cited by
- Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze.
Hilton JR, Simpson SR, Sherman ER, Raby-Smith W, Azvine K, Arribas M, Zou J, Deiana S, Hengerer B, Cahill EN. Hilton JR, et al. Eur J Neurosci. 2023 Jan;57(1):54-63. doi: 10.1111/ejn.15870. Epub 2022 Dec 14. Eur J Neurosci. 2023. PMID: 36382836 Free PMC article. - Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence.
Sari Y. Sari Y. OA Alcohol. 2013;1(1):6. doi: 10.13172/2053-0285-1-1-574. OA Alcohol. 2013. PMID: 24409344 Free PMC article. - Not all stressors are equal: behavioral and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization.
Daviu N, Delgado-Morales R, Nadal R, Armario A. Daviu N, et al. Front Behav Neurosci. 2012 Oct 29;6:69. doi: 10.3389/fnbeh.2012.00069. eCollection 2012. Front Behav Neurosci. 2012. PMID: 23112767 Free PMC article. - The effects of acute stress on Pavlovian-instrumental transfer in rats.
Pielock SM, Braun S, Hauber W. Pielock SM, et al. Cogn Affect Behav Neurosci. 2013 Mar;13(1):174-85. doi: 10.3758/s13415-012-0129-3. Cogn Affect Behav Neurosci. 2013. PMID: 23065681 - The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration.
Christianson JP, Paul ED, Irani M, Thompson BM, Kubala KH, Yirmiya R, Watkins LR, Maier SF. Christianson JP, et al. Behav Brain Res. 2008 Nov 3;193(1):87-93. doi: 10.1016/j.bbr.2008.04.024. Epub 2008 May 4. Behav Brain Res. 2008. PMID: 18554730 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical