Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro - PubMed (original) (raw)
Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro
T R Shew et al. Eur J Pharmacol. 1995.
Abstract
A grease-gap recording technique which allows the monitoring of presynaptic d. c. potentials without contamination of potentials from postsynaptic elements was used to examine presynaptic actions of glutamate agonists in the CA1 region of rat hippocampus. Presynaptic depolarizations through the activation of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)- and 2-amino-5-phosphonovaleric acid (APV)-sensitive receptors could be induced by applied agonists. In addition, the N-methyl-D-aspartate (NMDA)-induced depolarization was smaller in the presence of extracellular Mg2+ suggesting some similarity to postsynaptic NMDA receptors. The (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD)-induced depolarization was antagonized by L-2-amino-3-phosphonopropionic acid (L-AP3) but was also sensitive to APV+CNQX, creating ambiguity as to the type of receptors involved. These results suggest that the activation of glutamate autoreceptors leads to a presynaptic depolarization.
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